Study of Professor Han Fei’s medication rules in treating infantile epilepsy

Objective:By data mining,to analyze the characteristics of Professor Han Fei’s medication in the treatment of children with epilepsy,to explore the rules of medication,in order to provide reference for clinical treatment of children with epilepsy by Chinese medicine.Methods:From January 2008 to March 2021,we collected the diagnosis and treatment data of the children with epilepsy who were treated by Professor Han Fei in the outpatient department of Guang’Anmen Hospital of Chinese Academy of Medical Sciences.Using the software of IBM SPSS Statistics 24.0 and IBM SPSS Modeler 18.0,the characteristics and rules of Professor Hanfei’s Chinese materia medica used were summarized through the descriptive analysis,correlation analysis and cluster analysis of drug cumulative frequency,drug flavor,drug channel tropism and efficacy.Results:A total of 224 cases were included in this study,excluding 1 case with other neurological disorders.Finally,223 prescriptions were included,involving 176 kinds of Chinese materia medica and the total medication frequency was 4712.The first 10 highfrequency Chinese materia medica were Chaihu(95.52%),Bombyx batryticatus(94.17%),keels(83.41%),oysters(72.65%),earthworm(72.20%),fructus aurantii(66.37%),Scorpion(64.57%),Gastrodia elata(60.99%),Acorus gramineus(59.19%)and Dannan Xing(58.30%).The main Chinese materia medica used were mainly for suppressing hyperactive liver for calming endogenous wind,relieving exterior syndromes and tranquillizing mind.The medicine properties were mainly to be flat,slight cold,pungent,bitter and willing,and they were mainly for liver,lung and heart meridian tropism.Correlation Analysis:Bupleurum chinense,Bombyx batryticatus,Dragon Bone,oyster as its core medicine group,Semen Ziziphi spinosae and semen platycladi are effective strong correlation medicine pair.Three medicine combinations were obtained by cluster analysis.Conclusion:Hanshi has the characteristics of“calming liver,tranquilizing mind,calming endogenous wind,removing the phlegm and extravasated blood”in treating epilepsy.