加巴喷丁治疗难治性部分性癫痫的效果

Effect of gabapentin on refractory partial epilepsy

目的研究加巴喷丁治疗难治性部分性癫痫的效果。方法选择2019年2月—2020年2月本院收治的难治性部分性癫痫患者86例作为研究对象,按照随机数表法分为常规组和联合组两组,每组各43例。常规组采用卡马西平、托吡酯治疗,联合组在常规组用药的同时加用加巴喷丁治疗。比较两组疗效、治疗前、治疗6个月后发作频率、神经功能[神经功能缺损程度评分量表(NFDS评分)]、记忆功能[临床记忆量表(CMS评分)]、免疫功能(血清免疫球蛋白IgA、IgM、IgG水平)、氧化指标[丙二醛(MDA)、总抗氧化能力(T-AOC)]及不良反应。结果联合组总有效率为90.70%,高于常规组72.09%的(P<0.05);治疗6个月后联合组发作频率、NFDS评分低于常规组(P<0.05),CMS评分高于常规组(P<0.05);治疗6个月后联合组免疫球蛋白IgA、IgM、IgG水平低于常规组(P<0.05);治疗6个月后联合组血清MDA水平低于常规组(P<0.05),T-AOC高于常规组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论加巴喷丁治疗难治性部分性癫痫疗效显著,减少发作频率,改善神经、记忆功能,提升免疫功能,减轻氧化反应,安全性高。

Objective To study the effect of gabapentin on refractory partial epilepsy.Methods 86 patients with refractory partial epilepsy those admitted to our hospital from February 2019 to February 2020 were selected as the research objects.According to the random number table method,they were divided into two groups:the conventional group and the combined group,with 43 cases in each group.The conventional group was treated with carbamazepine and topiramate,and the combined group was treated with gabapentin at the same time on the bases of conventional group.The efficacy,frequency of attacks before and after 6 months of treatment,neurological function[Neural Function Impairment Degree Scale(NFDS Score)],memory function[Clinical Memory Scale(CMS score)],immune function(levels of serum immunity globulin IgA,IgM,and IgG),oxidation indicators[malondialdehyde(MDA),total antioxidant capacity(T-AOC)]and adverse reactions were compared between the two groups.Results The total effective rate of the combined group was 90.70%,which was higher than 72.09%of the conventional group(P<0.05).After 6 months of treatment,the combined group had lower seizure frequency and NFDS score than the conventional group,and the CMS score was higher than the conventional group(P<0.05).After 6 months,the immunoglobulin IgA,IgM,and IgG levels in the combined group were lower than those in the conventional group(P<0.05).After 6 months of treatment,the serum MDA level in the combined group was lower than that in the conventional group,and T-AOC was higher than that in the conventional group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Gabapentin is effective in the treatment of refractory partial epilepsy,reducing the frequency of seizures,improving nerve and memory functions,enhancing immune function,reducing oxidative reactions,and having high safety.