乙型病毒性肝炎相关肝内胆管癌致病机制研究进展

Advances in study on pathogenesis of hepatitis B virus-associated intrahepatic cholangiocarcinoma

肝内胆管癌发病率仅次于肝细胞癌位列原发性肝癌第二位,近20年来在全球范围内特别东南亚国家呈倍增的态势。肝内胆管癌的致病因素主要包括肝内胆管结石、原发性硬化性胆管炎、肝吸虫病等,近年来乙型肝炎病毒感染亦被发现为肝内胆管癌发生的重要病因。本文就乙型病毒性肝炎相关肝内胆管癌潜在发病机制进行综述。

The incidence of intrahepatic cholangiocarcinoma ranks secondly only to hepatocellular carcinoma as primary liver cancerwith a doubledincrease worldwide,especially in Southeast Asian countries over the past 20 years.The main pathogenic factors for intrahepatic cholangiocarcinoma include hepatolithiasis,primary sclerosing cholangitis,liver fluke disease,and so on.Recently,hepatitis B virus infection has been identified as important etiology of intrahepatic cholangiocarcinoma.This article provides a review of the potential pathogenesis of hepatitis B virus-associated intrahepatic cholangiocarcinoma.