生物标志物在急性主动脉综合征诊断及预后中的意义

The significance of biomarkers in diagnosis and prognosis of acute aortic syndrome

急性主动脉综合征(AAS)是一种危急且危及生命的疾病,包括主动脉夹层、主动脉壁内血肿、穿透性主动脉粥样硬化性溃疡和医源性外伤性主动脉损伤。AAS的诊断多基于病史、体格检查、生物标志物和影像技术等综合参数,也为临床预后以及选择个体化治疗提供参考。在生物标志物中,D-二聚体因具有灵敏度高和阴性似然比低的特点,是目前最为常用的AAS生物学标志物。其他特定的血清生物标志物还包括白细胞、C反应蛋白等用于检测和监测影响急性主动脉壁病变。本文就生物标志物在急性主动脉综合征诊断及预后中意义进行综述。

Acute aortic syndrome(AAS)is a critical and life-threatening condition that includes aortic dissection,intramural hematoma,penetrating atherosclerotic ulcers,and iatrogenic traumatic aortic injury.The diagnosis of AAS is mostly based on comprehensive parameters such as clinical history,physical examination,electrocardiogram,biomarker and imaging technology,and provide reference for clinical prognosis and selection of individualized treatment.Among biomarkers,D-dimer is the most commonly used biomarker of AAS due to its high sensitivity and low negative likelihood ratio.Other specific serum biomarkers include white blood cells,C-reactive protein,and fibrinogen are also used to detect and monitor lesions affecting the acute aortic wall.This article reviews the application and prospect of biomarkers in the diagnosis of acute aortic syndrome.