胸腺基质淋巴细胞生成素在不同皮肤病中的作用机制研究

Action mechanisms of thymic stromal lymphopoietin in various skin diseases

胸腺基质淋巴细胞生成素(TSLP)是一种与白细胞介素7(IL-7)类似的细胞因子,可以促进多种细胞的分化和增殖,并使其分泌Th2细胞因子,在机体免疫系统中发挥重要作用。近年来发现在许多皮肤病中TSLP的表达水平异常,在部分皮肤病中其水平高低还与疾病严重程度相关,提示TSLP可能是治疗多种皮肤病的潜在靶点。本文综述近年来TSLP在多种皮肤病(包括炎症性疾病、免疫性疾病、遗传性疾病和肿瘤性疾病)发生发展中的研究进展,为临床相关疾病的诊治提供依据和思路。

Thymic stromal lymphopoietin(TSLP),a cytokine similar to interleukin-7(IL-7),can promote the differentiation and proliferation of a variety of cells,promote the secretion of Th2 cytokines by these cells,and plays an important role in the immune system.In recent years,abnormal expression of TSLP has been found in many skin diseases,and its level is also related to the severity of some skin diseases,suggesting that TSLP may be a potential target for the treatment of various skin diseases.This review summarizes recent research progress in the role of TSLP in the occurrence and development of various skin diseases,including inflammatory diseases,immune diseases,genetic diseases and tumors,and provides a basis and some ideas for the diagnosis and treatment of related diseases.