噬菌体疗法及其在皮肤和泌尿生殖道感染中的应用与展望

Phage therapy and its application and prospects in skin and genitourinary tract infections

随着耐药菌的大量出现,给临床抗感染治疗带来严峻挑战。噬菌体疗法被认为是能够应对这种困境非常有希望的方法,已在很多学科得到探索和应用,在清除皮肤黏膜感染方面的疗效也得到证实,成为目前国际研究的热点。应用多种噬菌体混合的鸡尾酒疗法、噬菌体内溶酶以及噬菌体蛋白治疗耐药的金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌、克雷伯菌、变形杆菌等获得良好的效果。本文综述噬菌体疗法的背景、特征、发展特点及其在皮肤和泌尿生殖道感染中的应用和前景。

The emergence of a large number of drug-resistant bacteria has brought severe challenges to clinical anti-infection treatment.Phage therapy is considered to be a very promising method to cope with this dilemma,which has been explored and applied in many disciplines.Its efficacy has also been confirmed in clearing skin and mucous membrane infections,and it has become a hot spot in international.research.The use of phage cocktails,phage lysozymes and phage proteins has shown good efficacy in the treatment of drug-resistant Staphylococcus aureus,Pseudomonas aeruginosa,Escherichia coll,Klebsiella,Bacillus proteus,etc.This review summarizes the background,characteristics,development of phage therapy,and its application and prospects in skin and genitourinary tract infections.