摘要
辅助肝移植首创于1964年,是一种保留受者部分或全部肝脏的特殊肝移植术式。随着术式创新、病例积累以及对肝再生、移植免疫的机制研究的不断深入,辅助肝移植技术或将发挥更大的优势,在供体缺乏的情况下,最大范围地使病人获益。近年来,辅助肝移植在遗传代谢性肝病、不可切除性肝恶性肿瘤等治疗中不断创新,但辅助肝移植需要更严格的风险管理、更周密的术前评估和更加个体化的免疫调控。
Auxillary liver transplantation,first performed in1964,is a special procedure of liver transplant that preserves part or all of the liver of recipients.With the continuous surgical innovation,case accumulation,and the mechanism study of liver regeneration and transplant immunology,auxiliary liver transplantation showed superiority.Especially when it is lack of donors,patients could benefit from auxiliary liver transplantation.Recently,there has been progress in innovative applications of auxiliary liver transplantation in inherited metabolic liver disease and unresectable liver malignancies.Therefore,rigorous risk management,thorough perioperative evaluation,and individual regulation of immunosuppressive agents are essential.
作者
吕子成
张子杰
乔子耘
冯浩
夏强
LV Zi-cheng;ZHANG Zi-jie;QIAO Zi-yun(Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Institute of Transplantation,Shanghai Engineering Research Center of Transplantation and Immunology,SJTU Research Center of Transplantation and Immunology,Shanghai 200120,China)
出处
《中国实用外科杂志》
CAS
CSCD
北大核心
2021年第9期1073-1077,共5页
Chinese Journal of Practical Surgery
基金
国家自然科学基金委青年项目(No.81902388)
上海市自然科学基金(No.18ZR1424200)
上海交通大学转化医学(医工交叉)课题(No.YG2017QN54)。
关键词
肝移植
辅助肝移植
移植肿瘤学
移植免疫学
liver transplantation
auxiliary liver transplantation
transplant oncology
transplant immunology
