人类白细胞抗原G在口腔鳞癌中的表达及意义

Expression and clinical significance of human leucocyte antigen protein G in oral squamous cell carcinoma

目的:检测口腔鳞癌组织中人类白细胞抗原G(HLA-G)的表达,探讨其在口腔鳞癌发生发展中的意义。方法:采用免疫组织化学法检测48例口腔鳞癌癌巢及癌旁组织,20例正常口腔黏膜中HLA-G的表达情况,探究分析与病理参数之间的相关性。结果:HLA-G分子在口腔鳞癌组织中的阳性表达率为70.8%(34/48),在癌旁组织中为8.3%(4/48),而在正常口腔黏膜组织中无表达(0/20)。HLA-G分子表达与有无淋巴结转移有显著相关性(P=0.005),但其与年龄及肿瘤分化程度等多项病理参数并无相关性(P>0.05)。结论:HLA-G分子在口腔鳞状细胞癌组织中表达明显高于癌旁及正常口腔黏膜组织,HLA-G分子促进了口腔鳞状细胞癌的发生发展。HLA-G分子与口腔鳞癌发生发展密切相关。

Objective:To explore and analyze the expression of human leukocyte antigen G(HLA-G)in oral squamous cell carcinoma(OSCC),and to confirm the correlation between HLA-G and OSCC.Methods:The expression of HLA-G in 48 cases of oral squamous cell carcinoma nests and adjacent tissues,and 20 cases of normal oral mucosa were detected by immunohistochemistry.Results:The positive expression rate of HLA-G was 70.8%(34/48)in OSCC and 8.3%(4/48)in paracancerous tissues,but no expression in normal oral mucosa(0/20).There was a significant correlation between HLA-G expression and lymph node metastasis(P=0.005),but there was no significant correlation between HLA-G expression and age and tumor differentiation(P>0.05).Conclusion:The expression of HLA-G in OSCC is significantly higher than that in adjacent OSCC and normal oral mucosa.HLA-G molecule promotes the occurrence and development of OSCC.It’s closely related to the occurrence and development of OSCC.