酒精性脂肪性肝病与细胞自噬研究进展

Research progress on alcoholic fatty liver disease and autophagy

长期大量摄入酒精可诱发酒精性肝病(alcoholic liver disease,ALD)。自噬是依赖于溶酶体的细胞分解代谢过程。脂噬作为大自噬,是一种选择性自噬形式,可将脂滴吞噬并与溶酶体融合,形成自噬溶酶体,将吞噬的脂滴降解为脂肪酸。长期摄入酒精会延缓脂噬,减缓脂质降解,破坏肝脏内脂肪燃烧功能,同时加速脂肪生成。本文就酒精性脂肪性肝病与细胞自噬的研究进展进行综述。

A large amount of alcohol intake can induce alcoholic liver disease(ALD).Autophagy is a cellular catabolism process which depends on lysosome.As a major autophagy,lipophagy is a form of selective autophagy,which can phagocytose lipids and fuse with lysosomes to form autophagosomes and degrade the phagocytic lipids into fatty acids.Long-term intake of ethanol will delay lipid digesting,slow down lipid degradation,destroy fat burning function in liver and accelerate fat generation.This article reviewed the progress of studies on how alcohol intake affects lipophagy.