脓毒症肝损伤与自噬

Sepsis liver damage and autophagy

肝脏作为维持人体生命活动的重要器官之一,参与生物合成、新陈代谢、生物转化和免疫防御等过程,易受感染、创伤和休克等因素的侵害,是脓毒症早期易受损害的器官之一。自噬是真核生物内普遍存在的生命现象,在生理状态下自噬保护细胞免受外来刺激。在脓毒症所致的多器官损伤过程中,自噬有一定的保护作用。本文就自噬与脓毒症肝损伤的最新研究进展进行综述。

As one of the important organs to maintain human life,liver is involved in the processes of biosynthesis,metabolism,biotransformation and immune defense.It is susceptible to infection,trauma,shock and other factors.It is one of the early vulnerable organs in sepsis.Autophagy is a ubiquitous life phenomenon in eukaryotes.Under physiological conditions,autophagy protects cells from external stimuli.In the process of multiple organ damage caused by sepsis,autophagy has a certain protective effect.This article reviewed the latest research progress on autophagy and sepsis liver injury.