Mortalin蛋白在胰腺癌组织中的表达及其与患者临床病理特征和预后的相关性

Expression of Mortalin protein in pancreatic cancer and its correlation with clinicopathological features and prognosis.

目的探讨Mortalin蛋白在胰腺癌组织中的表达与患者临床病理特征和预后的关系。方法选取2015年9月至2019年9月辽阳市中心医院收治的80例胰腺癌患者为研究对象,采用系统回顾性分析法分析所有患者的临床资料,分为研究组(80份癌组织标本)及对照组(80份癌旁组织标本,距肿瘤边缘4 cm处)。所有组织标本均采用免疫组织化学染色检测Mortalin蛋白的表达,比较Mortalin蛋白表达与胰腺癌患者临床病理特征关系。采用多因素Cox比例风险回归模型分析影响胰腺癌患者预后的相关因素。结果胰腺癌组织中Mortalin蛋白高表达率(77.50%)明显高于对照组(25.00%),差异有统计学意义(P<0.05)。Mortalin蛋白表达与胰腺癌患者的年龄、性别无明显相关(P>0.05),但Mortalin蛋白表达与胰腺癌患者的肿瘤分化程度、淋巴结转移及TNM分期的比较有显著相关(P<0.05);对单因素分析结果为:肿瘤低分化、淋巴结出现转移、TNMⅢ~Ⅳ期及Mortalin高表达患者生存时间均大幅度减少(P<0.05);对多因素Cox比例风险回归模型分析结果为:低分化、淋巴结出现转移、TNMⅢ~Ⅳ期及Mortalin高表达均为影响胰腺癌患者预后的独立危险因素(P<0.05)。结论Mortalin蛋白在胰腺癌组织中的表达水平增高,其表达水平与胰腺癌患者的分化程度、淋巴结转移、TNM分期均有显著相关,与胰腺癌的发生和发展有重要意义。

Objective To investigate the relationship between the expression of Mortalin protein and clinicopathological features and prognosis of pancreatic cancer.Methods Eighty patients with pancreatic cancer in Liaoyang Central Hospital from September 2015 to September 2019 were selected as the research objects.The clinical data of all patients were analyzed by systematic retrospective analysis.They were divided into study group(80 cancer tissue samples)and control group(80 adjacent tissue samples,4 cm away from the edge of tumor).All tissue samples were detected by immunohistochemical staining.The relationship between the expression of Mortalin protein and clinicopathological features of colon cancer was compared.Multivariate Cox proportional hazards regression model was used to analyze the prognostic factors of patients with pancreatic cancer.Results The high expression rate of Mortalin protein in pancreatic cancer(77.50%)was significantly higher than that in the control group(25.00%),the difference was statistically significant(P<0.05).There was no statistically significant difference between the expression of Mortalin protein and the age and gender of patients with pancreatic cancer(P>0.05),but there was statistically significant difference between the expression of Mortalin protein and the degree of tumor differentiation,lymph node metastasis and TNM stage of patients with pancreatic cancer(P<0.05).The survival time of patients with poor differentiation,lymph node metastasis,TNM stageⅢ~Ⅳand high expression of Mortalin were significantly reduced(P<0.05).Multivariate Cox proportional hazards regression analysis showed that poor differentiation,lymph node metastasis,TNM stageⅢ~Ⅳand high expression of Mortalin were independent risk factors for prognosis of patients with pancreatic cancer(P<0.05).Conclusion The expression level of Mortalin protein in pancreatic cancer is significantly correlated with the degree of differentiation,lymph node metastasis and TNM stage of pancreatic cancer,which is of great significance in the occurrence and development of pancreatic cancer.