DHA对动物脂代谢的调控作用及其在畜牧生产中的应用研究进展

Advances in the Regulation of Docosahexaenic Acid on Lipid Metabolism and Its Application in Animal Production

二十二碳六烯酸(Docosahexaenoic Acid,DHA)是影响动物机体脂代谢的关键因子之一,其主要通过调节胰高血糖素样肽1表达,提高肝脏激酶B1活性,激活磷酸腺苷激活蛋白激酶,抑制核因子κB的活化关键因子核因子κB抑制蛋白α(Inhibitor-αof Nuclear Transcription FactorκB,IκBα),使IκBα磷酸化受阻,抑制下游肿瘤坏死因子-α表达,调控脂代谢。本文就DHA对动物脂代谢的调控机制及其在动物生产方面的应用现状进行综述,旨在为提高畜禽生产性能提供参考。

Docosahexaenoic acid(DHA)is one of the key factors affecting the lipid metabolism of animals,which mainly regulates the expression of glucagon-like peptide-1 to block the phosphorylation of IкBαand enhances the activity of liver kinase B1,activates AMP-activated protein kinase,and inhibits the key factor of nuclear factor kappa B activation,nuclear factor-αof nuclear transcription factor kappa B(IкBα),to inhibit the expression of tumor necrosis factor-αdownstream,and regulate lipid metabolism.The regulatory mechanism of DHA on animal lipid metabolism and its application in animal production is reviewed in this paper,in order to provide references for improving the production performance of livestock and poultry.