腹腔镜肝癌根治术联合扶正解毒法治疗原发性肝癌的效果及对肿瘤标志物的影响

Application of Laparoscopic Radical Hepatectomy Combined with Fuzheng Jiedu Method in Patients with Primary Liver Cancer and Its Influence on Survival Time and Tumor Markers

目的:探讨腹腔镜肝癌根治术联合扶正解毒法在原发性肝癌患者中的临床应用效果及对其肿瘤标志物的影响。方法:选择2015年1月—2017年10月常州市金坛区人民医院收治的原发性肝癌患者140例,随机分为两组,各70例。对照组采用腹腔镜肝癌根治术治疗,观察组在对照组基础上联合扶正解毒法治疗,治疗4周后,对患者效果进行评估,比较两组近期疗效、证候积分及肿瘤标志物水平。结果:治疗4周后,观察组的近期有效率为81.43%,高于对照组的54.29%,差异有统计学意义(P<0.05);观察组的乏力(0.84±0.21)分、肋痛(0.91±0.24)分、纳差(0.87±0.23)分、腹水(0.94±0.27)分及腹胀评分(0.63±0.16)分均低于对照组,差异有统计学意义(P<0.001);观察组的血清甲胎蛋白(AFP)(13.49±1.21)μg/L、癌胚抗原(CEA)(3.22±0.46)ng/mL及糖类抗原199(CA199)(21.59±3.41)U/L水平均低于对照组,差异有统计学意义(P<0.001)。结论:腹腔镜肝癌根治术联合扶正解毒法治疗原发性肝癌能获得较好的近期疗效,可降低证候积分及肿瘤标志物水平,值得推广应用。

Objective To investigate the clinical effect of laparoscopic radical hepatectomy combined with Fuzheng Jiedu method in patients with primary liver cancer and its influence on survival time and tumor markers.Methods 140 patients with primary liver cancer from January 2015 to October 2017 were randomly divided into two groups,which 70 cases in each group.The control group was treated with laparoscopic radical hepatectomy and the observation group was treated with Fuzheng Jiedu method on the basis of the control group.The effect of the patients was evaluated 4 weeks after treatment and the follow-up of 2 years was completed.The short-term efficacy,syndrome score,tumor marker level and survival time of the two groups were compared.Results After 4 weeks of treatment,the short-term treatment efficiency of the observation group was 81.43%,which was higher than 54.29%of the control group(P<0.05).The fatigue(0.84±0.21),rib pain(0.91±0.24),anorexia(0.87±0.23),ascites(0.94±0.27)and abdominal distension score(0.63±0.16)in the observation group were lower than those in the control group(t=7.192,5.461,8.092,5.738,7.112,P<0.001).After 4 weeks of treatment,AFP(13.49±1.21)μg/L,CEA(3.22±0.46)ng/mL and CA199(21.59±3.41)U/L in the observation group were lower than those in the control group(t=5.498,6.635,6.223,P<0.001).Conclusion Laparoscopic radical hepatectomy combined with Fuzheng Jiedu method in patients with primary liver cancer can obtain a higher short-term curative effect,reduce the syndrome score and tumor markers level,which is worthy of promotion and application.