氯胺酮神经保护作用的研究进展

Research progress on neuroprotective effect of ketamine

氯胺酮是非竞争性NMDA受体拮抗剂,用作分离性麻醉药已有很长历史,近年研究表明氯胺酮可能有神经保护作用,可以改善患者的认知功能。文章通过综述相关文献,讨论氯胺酮在预防围手术期神经认知障碍,改善重度抑郁症患者、急性神经损伤患者和阿尔茨海默病患者的认知功能等情况中发挥神经保护作用的相关研究进展以及可能的机制。

Ketamine is a noncompetitive N-methyl-D-aspartate(NMDA)receptor antagonist,which has been used as a dissociative anesthetic.In recent years,It has been shown that ketamine may have neuroprotective effect,which can improve cognitive function.This article reviews the relevant literature and discusses the research progress of ketamine's neuroprotective effect in preventing perioperative neurocognitive disorder(PND)and improving the cognitive function of patients with major depressive disorder,patients with acute neurologic injury and patients with Alzheimer's disease as well as the possible mechanism.