纳布啡在围手术期的应用

Application of nalbuphine in perioperative period

纳布啡是一种半合成阿片受体激动-拮抗剂,具有镇痛作用强、疗效确切、不良反应轻等优势,在其他国家临床应用中展现良好的前景。纳布啡在国内上市时间短,临床应用及科研报道较少。文章通过介绍纳布啡药理特性及作用机制,综述其在围手术期的临床应用(包括麻醉诱导、预防性镇痛、术中及术后镇痛、治疗术后并发症等)以及目前的研究进展,为纳布啡更加安全、合理地应用于临床提供参考。

Nalbuphine,a semi-synthetic opioid receptor agonist-antagonist,has the advantages of strong analgesic effect,definite efficacy,and mild adverse reactions,which shows bright prospects in clinical application in other countries.However,there are few reports on clinical application and scientific research in China.Therefore,this review introduces the pharmacological properties and mechanism of nalbuphine,and describes its clinical application including anesthesia induction,prophylactic analgesia,intraoperative and postoperative analgesia,treatment of postoperative complications,etc.It will provide safer and more reasonable guidance for using nalbuphine in clinical anesthesia.