阵发性房颤患者生长分化因子-15的表达及其与炎症的相关性分析

The expression of GDF-15 and its correlation with inflammation in patients with paroxysmal atrial fibrillation

目的:通过检测阵发性房颤患者外周血生长分化因子-15(GDF-15)水平,探讨GDF-15单独以及结合其他炎症标志物与阵发性房颤的关系。方法:选择2019年11月—2020年4月于新疆维吾尔自治区人民医院心内科住院的49例非瓣膜性房颤患者作为房颤组,其中男27例,女22例,年龄35~79岁。另选一般资料与房颤组相匹配的39例窦性心律患者作为对照组,其中男19例,女20例,年龄45~82岁。测定两组患者血常规、GDF-15及心脏彩超各项指标。结果:两组GDF-15、左房内径(LAD)、白细胞(WBC)、中性粒细胞绝对值(N)、血小板分布宽度(PDW)、中性粒细胞淋巴细胞比值(NLR)、红细胞分布宽度(RDW)比较,差异有统计学意义(P<0.05)。GDF-15与WBC,RDW,NLR和C-反应蛋白(CRP)无相关性。LAD与GDF-15,RDW,PDW,NLR具有正相关性。多因素Logistic回归分析显示,GDF-15,RDW和LAD是发生阵发性房颤的独立危险因素。结论:GDF-15,RDW和LAD水平升高与非瓣膜性阵发性房颤的发生和维持有关,GDF-15,RDW和LAD是非瓣膜性阵发性房颤的独立危险因素。

Objective:To explore the relationship between paroxysmal atrial fibrillation and growth differentiation factor-15(GDF-15)alone and in combination with other inflammatory markers by detecting the level of GDF-15 in peripheral blood of patients with paroxysmal atrial fibrillation.Methods:All 49 patients with non-valvular atrial fibrillation admitted in the department of Cardiology of people's Hospital of Xinjiang Uygur Autonomous Region from November 2019 to April 2020 were selected as atrial fibrillation group,including 27 males and 22 females,aged from 35 to 79.Another 39 patients with sinus rhythm matched with the general data of atrial fibrillation group were selected as the control group.There were 19 males and 20 females,aged from 45 to 82 years.The general data were collected,the blood routine and GDF-15 were tested,and the indexes of cardiac color ultrasound were determined.Results:There were significant differences in left atrial diameter(LAD),whitebloos cell(WBC),neutrophil(N),platelet distribution width(PDW),neutrophil lymphocyte ratio(NLR),red blood cell distribution width(RDW)and GDF-15 between atrial fibrillation group and non-atrial fibrillation group.There was no correlation between GDF-15 and WBC,RDW,NLR and C-reactive protein(CRP).LAD was positively correlated with GDF-15,RDW,PDW and NLR.Multivariate logistic regression analysis showed that GDF-15,RDW and LAD were independent risk factors for atrial fibrillation.Conclusion:The elevated levels of RDW,GDF-15 and LAD are related to the occurrence and maintenance of non-valvular atrial fibrillation.GDF-15,RDW and LAD are independent risk factors for atrial fibrillation.