牡荆素预防和治疗疾病作用机制研究进展

Research Progress on the Mechanism of Vitexin in Preventing and Treating Diseases

牡荆素是一种天然黄酮类化合物,具有很强的抗氧化性,可有效清除体内的氧自由基,还可以改善血液循环,降低胆固醇,抑制炎性生物酶的渗出,并具有抗心肌梗死、抗菌、抗肿瘤等药理作用,目前应用于各大疾病的防护与治疗中。本文阐述了牡荆素通过调节线粒体途径、MAPK途径、AKT途径、自噬能力以及相关凋亡蛋白(p53、Bcl-2、Bax和caspase等)对各种疾病治疗的机制,并对牡荆素的应用前景进行展望。

Vitexin is a natural flavonoid. It has strong antioxidant properties, can effectively remove oxygen free radicals in the body, can improve blood circulation, reduce cholesterol, and inhibit exudation of inflammatory organisms enzymes. It also has anti-myocardial infarction, antibacterial, antitumor and other pharmacological effects, therefore, it is currently used in the protection and treatment of major diseases. This article reviews the mechanism of vitexin treatment of various diseases through regulating, mitochondrial pathway, MAPK pathway, AKT pathway, autophagy ability and related apoptotic proteins(p53, Bcl-2, Bax and caspase etc.), and prospects the application prospects of vitexin.