左卡尼汀联合促红细胞生成素治疗老年血液透析患者肾性贫血效果

Effect of L-carnitine Combined with Erythropoietin on Renal Anemia in Elderly Hemodialysis Patients

目的:探讨左卡尼汀联合促红细胞生成素(EPO)治疗老年血液透析患者肾性贫血效果。方法:选取云南省红河州第三人民医院肾内科在2018年6月—2020年6月接受血液透析的老年肾性贫血患者76例作为研究对象,按随机数表法分为治疗组和对照组,每组各38例,每组对照组采用EPO治疗,治疗组在EPO的基础上给予左卡尼汀治疗,对比两组患者的临床疗效、两组患者治疗前后Hb和HCT水平以及两组患者不良反应发生情况。结果:治疗组疗效总有效率明显高于对照组;治疗前两组间Hb、HCT水平比较,治疗组治疗后Hb (102.85±6.89) g/L、HCT (33.79±1.25)%水平均高于对照组;治疗组患者的不良反应发生率略高于对照组(52.63%VS 47.37%,P>0.05)。结论:左卡尼汀联合EPO治疗老年血液透析患者,可明显改善肾性贫血的临床疗效、提高Hb、HCT水平,值得临床上推广应用。

Objective:To investigate the effect of L-carnitine combined with erythropoietin(EPO)in the treatment of renal anemia in elderly hemodialysis patients.Methods:A total of 76 elderly patients with renal anemia who underwent hemodialysis from June 2018 to June 2020 in the hospital were selected as the research objects,and they were divided into treatment group and control group according to the random number table method,with 38 cases in each group.The control group was treated with EPO,and the treatment group was treated with L-carnitine on the basis of EPO.The clinical efficacy,the levels of Hb and HCT before and after treatment and the occurrence of adverse reactions in the two groups were compared.Results:The total effective rate of curative effect in the treatment group was significantly higher than that in the control group.There was no statistically significant difference in Hb and HCT levels between the two groups before treatment.After treatment,Hb(102.85±6.89)g/L and HCT level(33.79±1.25)%in the treatment group were higher than those in the control group(P<0.05).The incidence of adverse reactions in the treatment group was slightly higher than that in the control group(52.63%VS 47.37%,P>0.05).Conclusion:Levocarnitine combined with EPO in the treatment of elderly hemodialysis patients can significantly improve the clinical efficacy of renal anemia,significantly increase the levels of Hb and HCT,and the incidence of adverse reactions after treatment is not significantly different.It is worthy of clinical application.