摘要
异腈类化合物因其特殊的结构,已经成为合成含氮杂环化合物常用的合成子.这种含氮杂环骨架的构建方法广泛应用于有机化学、药物化学以及高分子科学等领域中.论文结合活泼亚甲基异腈在构建含氮杂环化合物方面相关研究进展,同时结合了环丙烯酮的反应特点,研究了异氰基乙酸乙酯与环丙烯酮[3+3]环合反应.该反应为4-羟基吡啶化合物提供了一种高效的合成新方法.并且,该方法具有反应条件温和、操作简便等优点.
Isonitriles have been used as common synthesizers of nitrogen-containing heterocyclic compounds because of their special structure.This method of constructing nitrogen-containing heterocyclic skeleton has been widely used in organic chemistry,pharmaceutical chemistry and polymer science.In this paper,the cyclization reaction of active methylene isonitrile and cyclopropenone[3+3]was studied,combined with the related research progress and existing problems of active methylene isonitrile in the construction of nitrogen-containing heterocyclic compounds,and combined with the reaction characteristics of cyclopropenone.This reaction provides a new and efficient method for the synthesis of 4-hydroxypyridine compounds.In addition,this method has the advantages of mild reaction conditions,simple operation and high yield.
作者
冯万忠
陈哲
FENG Wanzhong;CHEN Zhe(School of Materials Science and Engineering,Jilin 132022,China)
出处
《吉林化工学院学报》
CAS
2021年第9期88-96,共9页
Journal of Jilin Institute of Chemical Technology
基金
吉林省教育厅项目(JJKH20200243KJ)
吉林市科技局科技创新创业人才培育计划(20190104169)。
关键词
异腈
环丙烯酮
吡啶化合物
环合反应
isocyanoacetate
cyclopropenone
pyridine compound
cyclization reaction