摘要
蓝舌病毒(Bluetongue virus,BTV)作为由媒介昆虫库蠓传播的引起反刍动物蓝舌病(Bluetongue,BT)的病原微生物,同时也是研究无囊膜病毒(Non-enveloped virus)释放机制的经典模型。文中以BTV侵染细胞及组装为始,对BTV诱导细胞自噬并通过多囊泡体以细胞外囊泡形式释放、BTV诱导细胞凋亡而裂解释放、BTV从质膜出芽释放的不同途径以及BTV关键非结构蛋白NS3在调控BTV释放过程中作用机制的研究进展进行综述,为进一步了解BTV感染、增殖、释放的分子机制提供参考。
Bluetongue virus(BTV) causes Bluetongue(BT) of ruminants vectored by culicoides midges. It is also a classic model for studying the release mechanism of non-enveloped virus. This review begins with the infection and assembly of BTV, then summarizes the advances of different ways of releasing BTV. This includes BTV-induced autophagy and the release as extracellular vesicles via multivesicular bodies, BTV-induced apoptosis and the lytic release, as well as different pathways of release through budding via plasma membrane. The regulatory mechanisms of NS3 which is a key non-structural protein during the release of BTV are also discussed, providing a basis for further understanding the molecular mechanisms underpinning the infection, proliferation and release of BTV.
作者
林俊泓
王让
赵瑶
陈玉娟
马鲜平
易华山
Junhong Lin;Rang Wang;Yao Zhao;Yujuan Chen;Xianping Ma;Huashan Yi(College of Veterinary Medicine,Southwest University,Chongqing 402460,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2021年第9期3179-3189,共11页
Chinese Journal of Biotechnology
基金
重庆市基础研究与前沿探索专项项目基金(No.cstc2018jcyj AX0615)
中央高校基本科研业务专项基金(Nos.XDJK2018C060,XDJK2018C059)
国家重点研发计划(No.2018YFD0501705)资助。