循环肿瘤细胞在大肠癌诊疗中的研究进展

Recent advances in diagnosis and treatment of colorectal cancer in circulating tumor cells

循环肿瘤细胞(CTC)是存在于循环系统中的肿瘤细胞,是液体活检的重要组成部分。大肠癌(CRC)是我国最常见的恶性肿瘤之一,其发病率和死亡率均呈上升趋势。CTC是大肠癌转移和复发的关键环节,在大肠癌发生的各时期均存在。研究表明,CTC的数量及类型与大肠癌患者的诊断、预后及治疗反应等相关,具有巨大的临床应用前景。文章将对大肠癌CTC的检测方法、临床价值等进行总结。CTC作为液体活检的一种形式,可应用于大肠癌患者的预后、治疗反应以及肿瘤复发的检测等重要环节,在促进大肠癌患者实施精准医疗方面具有非常广阔的潜力。

Circulating tumor cells(CTCs)are tumor cells present in the circulatory system and are an important component of liquid biopsies.Colorectal cancer(CRC)is one of the most common malignant tumors in China,and its incidence and mortality are increasing.CTC exists in all stages of colorectal cancer and is the key link between colorectal cancer metastasis and recurrence.Studies have shown that the number and type of CTC are related to the diagnosis,prognosis and treatment response of patients with colorectal cancer,which has great prospects for clinical application.This article summarized the detection methods and clinical value of CTC in colorectal cancer.As a form of liquid biopsy,CTC can be applied to the prognosis,treatment response and detection of tumor recurrence of patients with colorectal cancer.It has very broad potential in promoting the implementation of precision medicine for patients with colorectal cancer.