肠道菌群对骨骼肌的影响及SCFAs介导“肠-肌轴”的机制研究进展

Research progress in the effect of gut microbiome on skeletal muscle and mechanism of SCFAs mediated "gut-muscle axis"

肠道微生物是人类健康的重要组成部分,主要通过分解代谢生成具有生物活性的效应分子,调节宿主各重要脏器的生理功能,如肝、肺、脑等。骨骼肌被认为是人体最大的器官,对机体自主运动、姿势维持和代谢稳态至关重要。近年来,越来越多的研究揭示了骨骼肌与肠道菌群之间的重要生物学联系,认为肌肉功能在很大程度上依赖于肠道菌群的数量及结构,创新性提出"肠-肌轴"理论。该文综述肠道菌群对骨骼肌的影响及短链脂肪酸(SCFAs)介导"肠-肌轴"的机制研究进展,并对后续研究提出建议,以期为基于肠道菌群干预改善肌肉功能和体能表现提供理论参考。

Gut microbiome is a critical contributor to host health.It mostly through production of effector molecules possessing biological activity of catabolism modulates metabolic responses at different organ sites including liver,lung,and brain.Skeletal muscle is considered as the largest organ in the body,playing a pivotal role in voluntary movements,postural maintenance and energy homeostasis.Within the past few years,accumulating evidences have revealed biologically important association between the gut microbiota and skeletal muscle and demonstrated muscle function greatly depend on the bacterial population and structure,resulting in a novel and intriguing concept of"gut-muscle axis".This article aims at reviewing the modulatory effects and potential mechanisms of gut microbiota on skeletal muscle and mechanism of short-chain fatty acids(SCFAs)mediated"gut-muscle axis",as well as making recommendations on future research in order to provide a theoretical reference for improving muscle function and physical performance based on gut microbiota intervention.