肠道菌群介导的免疫反应与高血压和慢性肾脏病的关系研究进展

Research progress on the relationship of intestinal flora-mediated immune response to hypertension and chronic kidney disease

肠道菌群被认为与多种疾病相关,其中,肠道菌群与高血压、慢性肾脏病发生及发展的相关性研究近年来取得了较大进展。高血压和慢性肾脏病的发生、发展破坏了原有的肠道菌群组成,进而又促进了高血压和慢性肾脏病的发展。高血压、慢性肾脏病与肠道菌群改变的因果关系及其确切机制仍需进一步探讨。该文回顾了高血压和慢性肾脏病患者的肠道微生物组成,重点总结了共生微生物影响宿主免疫对原发疾病进展的作用,阐述了肠道菌群介导的免疫反应与高血压、慢性肾脏病之间除细菌细胞壁及脂多糖外主要通过短链脂肪酸、血管紧张素Ⅱ、氧化三甲胺等相互联系,以期为寻找治疗高血压和慢性肾脏疾病的潜在方法提供参考。

Intestinal flora is increasingly considered to be associated with multiple diseases,such as insulin resistance,bile acid metabolism and inflammatory reaction.Research on the relationship of intestinal flora to the occurrence and development of hypertension and chronic kidney disease has made remarkable progress in recent years.The occurrence and development of hypertension and chronic kidney disease disrupt the original gut microbiota composition,further contribute to the advancement of hypertension and chronic kidney disease.So far,further discussion is needed on the causality and exact mechanism of intestinal flora to hypertension and chronic kidney disease.The composition of intestinal microorganisms in hypertension and chronic kidney disease has been reviewed in present paper,and focused on the role of symbiotic microorganisms in affecting the host immunity and the progress of the primary disease,and summarized the relationship of intestinal flora mediated immune response to hypertension and chronic kidney disease,mainly interlinked each other through short-chain fatty acids,angiotensinⅡand trimethylamine oxide to provide the basis for finding potential treatment methods for hypertension and chronic kidney disease.