苎叶蒟中1个新的含氮木脂素

A novel nitrogen-bearing lignan from Piper boehmeriifolium

目的对苎叶蒟Piper boehmeriifolium的枝叶部位进行化学成分研究。方法采用硅胶、RP-C_(18)柱色谱、Sephadex LH-20凝胶柱色谱和半制备HPLC等方法进行分离和纯化,并综合运用IR、HR-ESI-MS、^(1)H-NMR、^(13)C-NMR、DEPT、HSQC、HMBC等方法鉴定化合物的结构。结果从苎叶蒟乙醇提取物中分离得到15个化合物,分别鉴定为3-(3,4-methylenedioxybenzyl)-4-(3,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione(1)、2E,4E-decadienoylpiperidide(2)、2E-decenoylpiperidide(3)、墙草碱(4)、piperchabamide B(5)、假蒟亭碱(6)、piperdardine(7)、胡椒新碱(8)、胡椒碱(9)、二氢荜茇明宁碱(10)、chingchengenamide A(11)、假荜茇酰胺B(12)、guineensine(13)、荜茇宁(14)和kusunokinin(15)。结论化合物1为新化合物,命名为胡椒木脂酰亚胺,化合物2、3、7、8、10和15为首次从该植物中分离得到。

Objective To study the chemical constituents from twigs and leaves of Piper boehmeriifolium.Methods The chemical constituents were separated and purified by silica gel,RP-C_(18) column chromatography,Sephadex LH-20 gel column chromatography and semi-preparative HPLC.The structures of them were fully determined based on spectroscopic analysis including IR,HR-ESI-MS,^(1)H-NMR,^(13)C-NMR,DEPT,HSQC,and HMBC spectra.Results Fifteen compounds were isolated from the ethanol extract of P.boehmeriifolium.The structure of 1 was identified as 3-(3,4-methylenedioxybenzyl)-4-(3,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione(1),and the other known compounds were identified as 2E,4E-decadienoylpiperidide(2),2E-decenoylpiperidide(3),pellitorine(4),piperchabamide B(5),sarmentine(6),piperdardine(7),piperanine(8),piperine(9),4,5-dihydropiperlonguminine(10),chingchengenamide A(11),retrofractamide B(12),guineensine(13),piperlonguminine(14)and kusunokinin(15).Conclusion Compound 1 is a novel compound and named as piperliganimide,compounds 2,3,7,8,10 and 15 were isolated from the plant for the first time.