基于数据挖掘分析含天麻方剂的配伍规律及应用特点

Based on Data Mining to Analyze the Compatibility Law and Application Characteristics of Prescriptions Containing Gastrodia Elata

目的基于数据挖掘探讨含天麻方剂的配伍规律及应用特点,为临床科学、规范使用天麻提供参考。方法以国家人口与健康科学数据共享平台收录的含天麻方剂为研究对象,利用Microsoft Office Excel 2017、IBM SPSS Modeler 18.0、IBM SPSS Statistics 23.0对纳入方剂进行中药频数统计、关联规则分析和聚类分析。并使用Cytoscape 3.7.2软件构建网络可视图。结果共纳入含天麻方剂146首,常用于治疗偏头痛、癫痫等神经系统疾病。286味中药以温性、寒性居多;药味以辛、苦为主;归经以肝经、肺经、脾经最常见。与天麻配伍的高频中药有川芎、当归、钩藤、全蝎、甘草等;高频中药关联规则分析显示,支持度较高药对组合有“天麻-川芎”“天麻-当归”“天麻-钩藤”;3味药组合中“川芎-当归-天麻”的支持度最高;4味药组合中“天麻-白术-茯苓-半夏”的支持度最高。治疗偏头痛时,天麻常与川芎、当归、白芷、钩藤等配伍,关联规则分析得到治疗偏头痛的药对组合17项,3味药组合12项,4味药组合4项;聚类分析得到治疗偏头痛的核心基本方5首。结论含天麻方剂的中药药性以温、寒居多,药味以辛、苦为主,归经多见肝经、肺经;含天麻方剂多具有滋补肝肾、平肝潜阳、活血化瘀之功效,临床主治偏头痛、癫痫等神经系统疾病。

Objective Based on data mining,the compatibility rules and application characteristics of Gastrodia elata-containing prescriptions are discussed,which can provide reference for clinical scientific and standardized use of Gastrodia elata.Methods Taking the prescriptions containing Gastrodia elata included in the national population and health science data sharing platform as the research object,we used Microsoft Office Excel 2017,IBM SPSS Modeler 18.0,and IBM SPSS Statistics 23.0 to perform traditional Chinese medicine frequency statistics,association rule analysis,and cluster analysis on the included prescriptions.And Cytoscape 3.7.2 software was applied to build a viewable network.Results The study included a total of 146 prescriptions containing Gastrodia elata,which are often used to treat neurological diseases,such as migraine and epilepsy.286 Chinese medicines were mostly warm and cold.Medical tastes were mainly pungent and bitter.The most common channel tropism were the liver,lung and spleen meridian.Compatibility with the high-frequency Chinese medicines and Gastrodia elata included Ligusticum chuanxiong,Angelica sinensis,Uncaria,scorpion,licorice,etc.Association rules analysis of high-frequency Chinese medicine demonstrated medicine pair combinations with high support threshold included“Rhizoma gastrodia-Ligusticum chuanxiong”“Rhizoma gastrodia-Angelica sinensis”and“Rhizoma gastrodia-Uncaria”.“Ligusticum chuanxiong-Angelica sinensis-Rhizoma gastrodia”had the highest support threshold among the three herb medicine combination;“Rhizoma gastrodia-Atractylodes macrocephala Koidz-Poria cocos-Pinellia ternata”in the four herb medicine combination had the highest support threshold.In the treatment of migraine,Rhizoma gastrodia was often compatible with Ligusticum chuanxiong,Chinses angelica,Angelica dahurica,Uncaria,etc.Association rule analysis implied that there are 17 drug combinations for the treatment of migraine,12 items of the three herb medicine combination,and 4 items of the four herb medicine combination.5 core basic prescriptions for migraine treatment were obtained by cluster analysis.Conclusion Prescriptions containing Gastrodia elata are mostly warm and cold,and their tastes are mainly pungent and bitter.The liver meridian and lung meridians are more common in the meridians.Prescriptions containing Gastrodia elata mostly have the effects of nourishing the liver and kidney,calming the liver and suppressing yang,and promoting blood circulation.These prescriptions are mainly used to cure migraine,epilepsy and other neurological diseases.