多烯磷脂酰胆碱联合门冬氨酸鸟氨酸、复方甘草酸苷治疗急性黄疸型肝炎患者的效果

Effect of Polyene Phosphatidylcholine Combined with Ornithine Aspartate and Compound Glycyrrhizin in Patients with Acute Icteric Hepatitis

目的分析多烯磷脂酰胆碱联合门冬氨酸鸟氨酸、复方甘草酸苷治疗急性黄疸型肝炎(AIH)患者的效果。方法选取济源市卫生学校附属医院2016年1月至2021年1月收治的100例AIH患者作为研究对象,依照治疗方案分为对照组(48例)和观察组(52例)。对照组接受门冬氨酸鸟氨酸、复方甘草酸苷治疗,观察组在对照组基础上联合多烯磷脂酰胆碱治疗。比较两组疗效、治疗前后临床症状评分、肝功能、血清炎症因子水平。结果观察组治疗总有效率高于对照组(P<0.05);治疗后,两组腹胀、恶心纳差、乏力、肝区不适症状评分均降低,且观察组低于对照组(P<0.05);治疗后,两组总胆红素(T-Bil)、谷丙转氨酶(ALT)、谷草转氨酶(AST)水平均降低,且观察组低于对照组(P<0.05);治疗后,两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均降低,且观察组低于对照组(P<0.05)。结论多烯磷脂酰胆碱联合门冬氨酸鸟氨酸、复方甘草酸苷治疗AIH效果确切,能有效缓解患者的临床症状,改善肝功能,降低炎症因子水平。

Objective To analyze the effect of polyene phosphatidylcholine combined with ornithine aspartate and compound glycyrrhizin in the treatment of patients with acute icteric hepatitis(AIH).Methods A total of 100 patients with AIH treated in the Affiliated Hospital of Jiyuan health school from January 2016 to January 2021 were selected and divided into control group(48 cases)and observation group(52 cases)according to the treatment scheme.The control group was treated with ornithine aspartate and compound glycyrrhizin,and the observation group was treated with polyene phosphatidylcholine on the basis of the control group.The curative effects,clinical symptom scores,liver function and serum inflammatory factor levels before and after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the symptom scores of abdominal distension,nausea,anorexia,fatigue and liver discomfort in the two groups were lower than those in the control group(P<0.05).After treatment,the levels of total bilirubin(T-Bil),alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in the observation group were lower than those in the control group(P<0.05).After treatment,serum tumor necrosis factor-α(TNF-α),the levels of interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).Conclusion Polyene phosphatidylcholine combined with ornithine aspartate and compound glycyrrhizin is effective in the treatment of AIH.It can effectively alleviate the clinical symptoms,improve liver function and reduce the level of inflammatory factors.