膦甲酸钠在宫颈癌前病变高危型HPV感染患者LEEP术后的应用价值

Application value of foscarnet sodium in patients with high-risk HPV infection of cervical precancerous lesions after LEEP

目的探究膦甲酸钠在宫颈癌前病变高危型人乳头瘤病毒(HPV)感染患者宫颈电热圈环切术(LEEP)术后的应用价值。方法选取2017年1月至2019年8月收治的100例宫颈癌前病变高危型HPV感染患者作为研究对象,根据简单随机化法将其分为对照组和试验组,各50例。两组均行LEEP治疗,对照组术后不做特殊处理,试验组术后给予膦甲酸钠治疗。比较两组的临床疗效及术后3、6、12个月的HPV持续感染情况、未见上皮内病变或恶性细胞(NILM)发生情况。结果试验组的治疗总有效率为98.00%,高于对照组的80.00%,差异具有统计学意义(P<0.05)。试验组术后3、6、12个月的HPV持续感染率均低于对照组,差异具有统计学意义(P<0.05)。试验组术后3、6、12个月的NILM发生率均高于对照组,差异具有统计学意义(P<0.05)。结论膦甲酸钠应用于宫颈癌前病变高危型HPV感染患者LEEP术后,能够更好地促使高危型HPV转阴,提高患者的治疗效果及NILM发生率,促进预后改善,意义重大,值得临床推广和应用。

Objective To explore the application value of foscarnet sodium in patients with high-risk human papillomavirus(HPV)infection of cervical precancerous lesions after loop electrosurgical excision procedure(LEEP).Methods A total of 100 patients with high-risk HPV infection of cervical precancerous lesions treated from January 2017 to August 2019 were selected as the research objects,and the patients were divided into control group and experimental group according to simple randomization method,with 50 cases in each group.Both groups were treated with LEEP,the control group was not given special treatment after operation,and the experimental group was given foscarnet sodium treatment after operation.The clinical efficacy,HPV persistent infection and the occurrence of negative for intraepithelial lesion or malignancy(NILM)at 3,6 and 12 months after operation were compared between the two groups.Results The total effective rate of treatment in the experimental group was 98.00%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The rate of HPV persistent infection in the experimental group at 3,6 and 12 months after operation were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of NILM in the experimental group at 3,6 and 12 months after operation were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Foscarnet sodium applied in patients with high-risk HPV infection of cervical precancerous lesions after LEEP can better promote the negative conversion of high-risk HPV,improve the treatment effect and the incidence of NILM of patients,and promote the improvement of prognosis.It is of great significance and is worthy of clinical promotion and application.