不同剂量阿托伐他汀钙联合苯磺酸氨氯地平治疗缺血性脑血管病微出血的效果比较

Comparison on the effects of different doses of atorvastatin calcium combined with amlodipine besylate in the treatment of microbleeds of ischemic cerebrovascular disease

目的比较不同剂量阿托伐他汀钙联合苯磺酸氨氯地平治疗缺血性脑血管病微出血的效果。方法选取100例缺血性脑血管病微出血患者为研究对象,根据阿托伐他汀钙使用剂量不同分为A组、B组,每组50例。所有患者均接受对症处理及苯磺酸氨氯地平治疗,在此基础上A组、B组分别给予阿托伐他汀钙40、20 mg/d。比较两组的临床疗效、氧化应激指标、血管内皮功能指标及不良反应发生情况。结果A组的治疗总有效率为96.00%,高于B组的82.00%(P<0.05)。治疗后,A组的MDA水平低于B组,GSH-Px、SOD水平高于B组(P<0.05)。治疗后,A组的VEGF、NO水平高于B组,ET-1水平低于B组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论大剂量阿托伐他汀钙联合苯磺酸氨氯地平治疗缺血性脑血管病微出血的效果优于小剂量,可改善氧化应激指标及血管内皮功能指标,且不增加不良反应。

Objective To compare the effects of different doses of atorvastatin calcium combined with amlodipine besylate in the treatment of microbleeds of ischemic cerebrovascular disease.Methods One hundred patients with microbleeds of ischemic cerebrovascular disease were selected as the research objects.According to the dosage of atorvastatin calcium,the patients were divided into group A and group B,with 50 cases in each group.All patients received symptomatic treatment and amlodipine besylate treatment,the group A and group B were given atorvastatin calcium 40 and 20 mg/d respectively on this basis.The clinical efficacy,oxidative stress indexes,vascular endothelial function indexes and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the group A was 96.00%,which was higher than 82.00%in the group B(P<0.05).After treatment,the level of MDA in the group A was lower than that in the group B,while the levels of GSH-Px and SOD were higher than those in the group B(P<0.05).After treatment,the levels of VEGF and NO in the group A were higher than those in the group B,while the level of ET-1 was lower than that in the group B(P<0.05).There was no significant difference in the total incidence of adverse reoutions between the two groups(P>0.05).Conclusion High dose of atorvastatin calcium combined with amlodipine besylate in the treatment of microbleeds of ischemic cerebrovascular disease has a better effect than low dose.It can improve the oxidative stress indexes and vascular endothelial function indexes,and does not increase adverse reactions.