双水平气道正压通气治疗慢阻肺伴Ⅱ型呼吸衰竭的临床效果

Clinical effect of biphasic positive airway pressure ventilation in the treatment of chronic obstructive pulmonary disease with type Ⅱ respiratory failure

目的分析双水平气道正压通气治疗慢阻肺伴Ⅱ型呼吸衰竭的临床效果。方法回顾性选取2017年10月至2020年10月本院收治的80例慢阻肺伴Ⅱ型呼吸衰竭患者,依据治疗方法将其分为对照组和研究组,每组40例。对照组给予常规治疗+鼻导管持续低流量吸氧,研究组给予常规治疗+双水平气道正压通气。比较两组的血气分析指标、血气分析指标改善时间、住院时间、临床疗效、生存情况及住院期间并发症发生情况。结果治疗前,两组的SaO_(2)、PaO_(2)、PaCO_(2)、pH比较,差异无统计学意义(P>0.05);治疗后,两组的SaO_(2)、PaO_(2)、pH均高于治疗前,PaCO_(2)低于治疗前,且研究组优于对照组,差异具有统计学意义(P<0.05)。研究组的血气分析指标改善时间、住院时间均显著短于对照组,差异具有统计学意义(P<0.05)。研究组的缓解率、随访6个月存活率均显著高于对照组,差异具有统计学意义(P<0.05)。研究组住院期间并发症总发生率为5.00%,显著低于对照组的27.50%,差异具有统计学意义(P<0.05)。结论与鼻导管持续低流量吸氧相比,双水平气道正压通气治疗慢阻肺伴Ⅱ型呼吸衰竭的临床效果更显著,可有效改善患者的血气分析指标,促进其快速康复,降低并发症发生率。

Objective To analyze the clinical effect of biphasic positive airway pressure ventilation in the treatment of chronic obstructive pulmonary disease with type Ⅱ respiratory failure.Methods A total of 80 patients with chronic obstructive pulmonary disease with type Ⅱ respiratory failure treated in our hospital from October 2017 to October 2020 were selected retrospectively.The patients were divided into control group and study group according to the treatment methods,with 40 cases in each group.The control group was given routine treatment+continuous low flow oxygen inhalation through nasal catheter,while the study group was given routine treatment+biphasic positive airway pressure ventilation.The blood gas analysis indexes,improvement time of blood gas analysis indexes,hospital stay,clinical efficacy,survival and complications during hospitalization were compared between the two groups.Results Before treatment,there were no significant differences in SaO_(2),PaO_(2),PaCO_(2) and pH between the two groups(P>0.05);after treatment,the SaO_(2),PaO_(2) and pH of the two groups were higher than those before treatment,PaCO_(2) was lower than that before treatment,those of the study group were better than the control group,and the differences were statistically significant(P<0.05).The improvement time of blood gas analysis indexes and hospital stay in the study group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).The remission rate and survival rate during 6-month follow-up in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of complications during hospitalization in the study group was 5.00%,which was significantly lower than 27.50%in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with continuous low flow oxygen inhalation through nasal catheter,biphasic positive airway pressure ventilation in the treatment of chronic obstructive pulmonary disease with type Ⅱ respiratory failure has more significant clinical effect.It can effectively improve the blood gas analysis indexes of patients,promote their rapid recovery,and reduce the incidence of complications.