补阳还五汤加减治疗气虚血瘀型脑梗死的临床效果及对凝血-纤溶功能和miR-151a-3p、miR-210表达的影响

Clinical effect of modified Buyang Huanwu decoction on cerebral infarction of Qi deficiency and blood stasis type and its influences on coagulation-fibrinolysis function and the expression of miR-151a-3p and miR-210

目的探讨补阳还五汤加减治疗气虚血瘀型脑梗死的临床效果及对患者凝血-纤溶功能和miR-151a-3p、miR-210表达的影响。方法选取2017年6月至2020年6月收治的86例气虚血瘀型脑梗死患者,采用抽签法以单双号形式随机将其分为对照组(43例,常规西药治疗)和观察组(43例,常规西药+补阳还五汤加减治疗)。比较两组的治疗效果。结果观察组的治疗总有效率为95.35%,明显高于对照组的81.40%(P<0.05)。治疗后,观察组的PT、APTT长于对照组,t-PA水平高于对照组,PAI-1水平低于对照组(P<0.05)。治疗后,观察组的miR-151a-3p水平低于对照组,miR-210水平高于对照组(P<0.05)。结论补阳还五汤加减治疗气虚血瘀型脑梗死的临床效果显著,可提高患者凝血-纤溶功能,并有效改善miR-151a-3p、miR-210表达情况,值得临床推广应用。

Objective To explore the clinical effect of modified Buyang Huanwu decoction on cerebral infarction of Qi deficiency and blood stasis type and its influences on coagulation-fibrinolysis function and the expression of miR-151a-3p and miR-210.Methods A total of 86 patients with cerebral infarction of Qi deficiency and blood stasis type admitted from June 2017 to June 2020 were selected and randomly divided into control group(43 cases,conventional western medicine treatment)and observation group(43 cases,conventional western medicine+modified Buyang Huanwu decoction treatment)in the form of odd and even numbers by drawing lots.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 95.35%,which was significantly higher than 81.40%in the control group(P<0.05).After treatment,PT and APTT in the observation group were longer than those in the control group,t-PA level was higher than that in the control group,and the level of PAI-1 was lower than that in the control group(P<0.05).After treatment,the level of miR-151a-3p in the observation group was lower than that in the control group,and the level of miR-210 was higher than that in the control group(P<0.05).Conclusion Modified Buyang Huanwu decoction in cerebral infarction of Qi deficiency and blood stasis type has a significant clinical effect,it can improve the coagulation-fibrinolysis function and the expression of miR-151a-3p and miR-210,which is worthy of clinical promotion and application.