基于神经血管单元各组成部分保护作用的中药抗缺血性脑卒中的研究进展

Research progress on traditional Chinese medicine against ischemic stroke based on protective effect of each component of neurovascular unit

脑卒中是一种具有极高致死率的脑血管疾病,严重影响着人们的健康和生活。随着神经血管单元概念的提出,脑卒中的治疗从单一的神经元保护转变为对神经血管单元各组成部分的保护。中药具有多成分、多途径、多靶点等特点,在脑卒中治疗中受到广泛关注。中医认为,脑卒中的发病因素与“风”“痰”“瘀”“火”“气”“虚”密切相关,其中“虚”“瘀”“痰”贯穿脑卒中发生发展的始终。研究表明,从“虚”“瘀”“痰”论治的中药在脑卒中治疗中发挥着重要作用。综述了中药对缺血性卒中后神经血管单元各组成部分的保护作用。

Stroke is a cerebrovascular disease with high mortality,which seriously affects people’s health and life.With the concept of neurovascular unit proposed,the treatment of stroke has changed from a single neuron protection to the protection among the components of neurovascular unit.Traditional Chinese medicine has the characteristics of multi-component,multi-channel and multitarget,which has been widely concerned in the treatment of stroke.According to traditional Chinese medicine,the pathogenic factors of stroke are closely related to“wind”,“phlegm”,“stasis”,“fire”,“qi”and“deficiency”,among them,“deficiency”,“stasis”and“phlegm”run through the occurrence and development of stroke.Research shows that traditional Chinese medicine based on“deficiency”,“Yu”and“phlegm”syndrome differentiation plays an important role in the treatment of stroke.The protective effects of these traditional Chinese medicines on components of neurovascular unit after ischemic stroke were reviewed in this paper.