系统性红斑狼疮病人疲劳发生率的系统评价

Systematic evaluation of the incidence of fatigue in patients with systemic lupus erythematosus

目的:通过系统评价分析系统性红斑狼疮(systemic lupus erythematosus,SLE)病人疲劳发生情况。方法:计算机检索Web of Science、PubMed、CINAHL、中国生物医学文献数据库、中国期刊全文数据库、维普数据库、万方数据库中关于SLE病人疲劳的相关文献,检索时间均为建库至2020年9月1日。由2名研究者独立筛选文献、提取数据并对文献进行质量评价后,采用Stata 15.1软件进行Meta分析。结果:共纳入16篇文献,包含4396例SLE病人。Meta分析结果显示,SLE病人疲劳发生率为65.8%[95%CI(56.8%,74.8%)]。亚组分析结果显示,不同地区、不同人种、不同年龄、发表时间以及疲劳严重度量表评分截断值之间疲劳发生率存在差异,而病程和疾病活动度对疲劳发生率的影响不大。结论:现有证据表明,SLE病人疲劳发生率较高,不同地区、人种、年龄、发表时间和截断值等因素会对SLE病人疲劳的检出率产生影响。

Objective:To analyze the incidence of fatigue in patients with SLE by systematic review.Methods:Literature on fatigue in patients with SLE were searched from Web of Science,PubMed,CINAHL,CBM,CNKI,VIP and WanFang database.The retrieval time was from inception to September 1,2020.Two researchers independently screened the literature,extracted data and evaluated the risk of bias.Stata 15.1 software was used for Meta-analysis.Results:A total of 16 articles were included,involving 4396 SLE patients.Meta-analysis results showed that the incidence of fatigue in SLE patients was 65.8%[95%CI(56.8%,74.8%)].Subgroup analysis showed that there were differences in the incidence of fatigue among different regions,different races,different ages,publication time and cut-off value of Fatigue Severity Scale,but the course of disease and disease activity had little effect on the incidence of fatigue.Conclusion:Current evidences shows that the incidence of fatigue in SLE patients is higher.Different regions,races,ages,publication time and cut-off value will affect the detection rate of fatigue in SLE patients.