小儿喘息性疾病治疗中硫酸镁与氨茶碱的效果分析

Therapeutic effects of magnesium sulfate and aminophylline for wheezing disorders in children

目的探讨硫酸镁与氨茶碱在小儿喘息性疾病治疗中的疗效。方法选取2016年8月至2020年1月于本院接受治疗的196例小儿喘息性疾病患儿,随机分为常规组(n=64)、氨茶碱组(n=66)、硫酸镁组(n=66)。常规组给予常规治疗,氨茶碱组在常规组基础上给予氨茶碱静滴治疗,硫酸镁组在常规组基础上给予静滴小剂量硫酸镁治疗。比较3组患儿治疗效果、临床症状缓解时间、住院时间及不良反应。结果硫酸镁组治疗总有效率明显高于氨茶碱组和常规组,差异有统计学意义(P<0.05);硫酸镁组咳嗽消失时间、肺部喘鸣音消失时间、住院时间均短于氨茶碱组和常规组,差异有统计学意义(P<0.05);氨茶碱组不良反应发生率明显高于硫酸镁组和常规组(P<0.05),硫酸镁组与常规组不良反应发生率比较差异无统计学意义。结论在小儿喘息性疾病治疗中静脉滴注小剂量硫酸镁,能有效缓解患儿临床症状,提高治疗效果,安全可靠,值得临床推广运用。

Objective To explore the curative effect of magnesium sulfate and aminophylline in the treatment of asthmatic diseases in children.Methods 196 children with asthmatic disease treated in our hospital from August 2016 to January 2020 were randomly divided into conventional group(n=64),aminophylline group(n=66)and magnesium sulfate group(n=66).The conventional group was given conventional treatment,the ami-nophylline group was given aminophylline intravenous drip on the basis of the conventional group,and the magnesium sulfate group was given small dose magnesium sulfate intravenous drip on the basis of the conventional group.The treatment effect,clinical symptom relief,hospitalization time and adverse reactions among the three groups were compared.Results The total effective rate of magnesium sulfate group was significantly higher than that of aminophylline group and conventional group(P<0.05);the cough disappearance time,lung wheezing disappearance time and hospital-ization time of magnesium sulfate group were shorter than those of aminophylline group and conventional group,and the difference was statistically significant(P<0.05);the incidence of adverse reactions in aminophylline group was significantly higher than that in magnesium sulfate group and conventional group(P<0.05),there was no significant difference in the incidence of adverse reactions between magnesium sulfate group and con-ventional group.Conclusion In the treatment of children with asthmatic diseases,intravenous drip of small dose of magnesium sulfate can effective-ly relieve the clinical symptoms of children,improve the treatment effect,safe and reliable,which is worthy of clinical application.