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羊链球菌致病机制研究进展 被引量:2

Progress on Pathogenesis of Streptococcus zooepidemicus in Sheep
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摘要 羊链球菌病又称羊败血性链球菌病,是由C群马链球菌兽疫亚种引起的一种急性热性败血性传染病,病死率高达80%。人与发病羊只接触或食用被该菌污染的食品也可导致发病。近年来对羊链球菌病研究的热点之一是该菌的致病力及其致病机制。羊链球菌感染引起羊只发病的过程主要包括感染、黏附宿主细胞、入侵宿主细胞、损伤细胞和免疫逃避等过程。羊链球菌的毒力因子具有附着和侵袭机体细胞的作用,使细菌在羊只体内大量聚集,进而干扰机体的正常免疫功能引起疾病。论文综述了链球菌对宿主细胞的黏附作用以及链球菌对宿主的免疫逃避的机制,并阐述了链球菌在入侵机体细胞过程中发挥主要作用的毒力因子的种类、结构及其作用机制。通过对毒力因子的综述,为抑制毒力因子和防控羊链球菌病提供参考。 Streptococcus zooepidemicus infection in sheep,known as sheep septic streptococcal disease,is an acute febrile septic infectious disease caused by group C Streptococcus with a mortality up to 80%.Human beings will be infected if being contacted with sick sheep or eating food contaminated by the Streptococcus zooepidemicus.In recent years,one of the hotspots in the study of streptococcosis is the pathogenicity and the pathogenic mechanism of Streptococcus zooepidemicus.The disease mainly includes infection,the adhesion to host cells,the invasion to host cells,the damage to the cells,and the immune evasion.The virulence factor of Streptococcus zooepidemicus has the effect of adhesion and invasion,causing the excessive accumulation of bacteria in the body.Finally,the normal immune function is interfered and the sheep are infected.This article reviewed the adhesion of streptococci to host cells and the immune evasion mechanism of Streptococcus zooepidemicus to the host.It also described the types,structures,and mechanisms of virulence factors that streptococci play a major role in the process of invading cells.The goal of this article is to provide new ideas for the inhibition of virulence factors and the prevention and control of Streptococcus zooepidemicus infection.
作者 王明琼 李超 刘学通 董强 WANG Ming-qiong;LI Chao;LIU Xue-tong;DONG qiang(Agriculture and Animal Husbandry Service Center of Naidong District,Naidong,Tibet,856100,China;Agriculture and Animal Husbandry Service Center of Cuona District,Cuona,Tibet,856700,China;Shaanxi Varieties Developing and Thoroughbred Breeding Farm,Fufeng,Shaanxi,722203,China;College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi,712100,China)
出处 《动物医学进展》 北大核心 2021年第10期71-75,共5页 Progress In Veterinary Medicine
基金 陕西省科技计划项目(2019NY-082)。
关键词 羊链球菌 毒力因子 致病机制 黏附作用 免疫逃避 Streptococcus zooepidemicus virulence factor pathogenesis adhesion immune evasion
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