G型产气荚膜梭菌NetB毒素研究进展

Progress on NetB Toxin of Clostridium perfringens Type G

G型产气荚膜梭菌可引起鸡坏死性肠炎和肠毒血症,致病力强,在自然界中广泛存在,严重危害养鸡业的发展。坏死性肠炎B样毒素(necrotic enteritis B-like toxin,NetB)是近年来发现的是一种新的β-成孔毒素(β-pore-forming toxin,β-PFT),是G型产气荚膜梭菌的主要致病性毒素和保护性抗原,深入研究该毒素的结构功能及致病机理对于鸡坏死性肠炎的防控具有重要意义,但至今尚无相关系统性综述报道。鉴于此,论文主要对国内外关于G型产气荚膜梭菌的流行概况、NetB毒素的分子结构特征、生物学特性、致病机理及其相关防治制剂等方面的研究进行综述,为进一步基于NetB毒素研制鸡坏死性肠炎的防治制剂提供参考。

Clostridium perfringens type G can cause necrotic enteritis and enterotoxemia in chickens.It has strong pathogenicity and widely exists in nature,seriously endangering the development of chicken industry.Necrotic enteritis B-like toxin(NetB)is a newβ-pore forming toxin discovered in recent years.It is the main pathogenic toxin and protective antigen of C.perfringens type G.Further study on the structure,function,and pathogenic mechanism underlying the toxin effect is of great significance for the prevention and control of necrotic enteritis in chickens,but no systematic reviews have been published to date.This paper reviewed the epidemic status of type G C.perfringens domestically and internationally,as well as the molecular structural characteristics,biologic characteristics,pathogenic mechanism,and related prevention and treatment preparations of NetB toxin to provide the theoretical basis for further development of prevention and control preparations for necrotizic enteritis in chickens based on the NetB toxin.