双相障碍患者血清半胱氨酸、S100B蛋白与认知功能障碍程度的相关性研究

Correlation between serum cysteine,S100B protein and the degree of cognitive impairment in patients with bipolar disorder

目的研究双相障碍患者血清半胱氨酸(Hcy)、S100B蛋白与认知功能障碍严重程度的相关性。方法选取茂名市第三人民医院2019年1月到2021年2月收治的120例双相障碍患者作为研究对象,进行回顾性分析研究,根据是否伴有认知障碍将患者分为对照组[蒙特利尔认知评估量表评分(MoCA)≥26分,30例]、轻度组(21分≤MoCA<26分,60例)及重度组(MoCA评分<21分,30例)。分析3组患者长谷川痴呆量表(HDS)与简易精神状态检查表(MMSE)评分情况,检测3组受检者血清HCY、S100B蛋白,分析认知功能障碍与上述指标的相关性。结果3组患者治疗后血清Hcy显著低于治疗前,S100B蛋白显著低于治疗前,差异均有统计学意义(均P<0.05)。治疗前和治疗后3组间患者血清HCY和S100蛋白水平比较,差异均有统计学意义(均P<0.05);3组患者治疗后血清HCY显著高于治疗前,S100B蛋白显著低于治疗前,差异均有统计学意义(均P<0.05)。治疗前和治疗后3组间患者血清Hcy和S100蛋白水平比较,差异均有统计学意义(均P<0.05);治疗前和治疗后患者MoCA各项目评分与血清Hcy、S100B蛋白水平呈显著负相关性(P<0.05)。结论治疗前后血清Hcy、S100B蛋白与HDS、MMSE评分相同均会出现显著变化,且不同程度认知功能障碍患者出现明显差异。因此认为血清Hcy、S100B蛋白与患者认知功能障碍相关,有望成为判断病情和认知功能的依据。

Objective To study the correlation between serum cysteine(Hcy),S100B protein and the severity of cognitive impairment in patients with bipolar disorder.Methods A retrospective analysis of 120 patients with bipolar disorder admitted to the Third People's Hospital of Maoming City from January 2019 to February 2021 According to whether they had cognitive impairment,the patients were divided into control group[Montreal Cognitive Assessment Scale score(MoCA)≥26,30 cases],mild group(21≤MOCA<26,60 cases)and severe group(MoCA score<21,30 cases).The scores of Hasegawa Dementia Scale(HDS)and mini mental state examination(MMSE)were analyzed,the serum HCY and S100B proteins of the three groups were detected,and the correlation between cognitive impairment and the above indexes was analyzed.Results After treatment,the serum Hcy and S100B protein of the three groups were significantly lower than those before treatment(P<0.05).There were significant differences in serum Hcy and S100 protein levels between the three groups before and after treatment(P<0.05);The serum Hcy of the three groups after treatment was significantly higher than that before treatment,and the S100B protein was significantly lower than that before treatment(P<0.05).There were significant differences in serum Hcy and S100 protein levels between the three groups before and after treatment(P<0.05);There was a significant negative correlation between MOCA scores and serum Hcy and S100B protein levels before and after treatment(P<0.05).Conclusion before and after treatment,serum Hcy and S100B protein will change significantly with the same score as HDS and MMSE,and there are significant differences in patients with different degrees of cognitive impairment.Therefore,it is considered that serum Hcy and S100B proteins are related to patients'cognitive impairment,which is expected to be the basis for judging the condition and cognitive function.