血清ANGPT2、VEGFR-3、抵抗素水平在寻常型银屑病中的临床意义

Clinical Significance of Serum ANGPT2,VEGFR-3 and Resistin Levels in Psoriasis Vulgaris

目的:探讨血清血管生成素样蛋白2(ANGPT2)、血管内皮细胞特异性受体VEGF受体(VEGF receptors,VEGFR)-3、抵抗素(Resistin)水平在寻常型银屑病中的临床意义。方法:选择2017年9月—2020年6月在本院皮肤科就诊的寻常型银屑病患者60例作为病例组,同期选择本院体检的健康人员60例作为对照组。检测所有入选者的血清ANGPT2、VEGFR-3、抵抗素水平,调查病例组的银屑病面积与严重性指数(Psoriasis area and severity index,PASI)评分并进行相关性分析。结果:病例组的ANGPT2、VEGFR-3、抵抗素含量[(4.69±0.44)ng/ml、(10.83±1.47)ng/ml、(267.02±45.10)ng/ml]均高于对照组[(1.83±0.30)ng/ml、(8.02±2.15)ng/ml、(98.27±10.47)ng/ml],病例组的PASI评分高于对照组(P<0.05)。在病例组中,Pearson分析显示PASI评分与血清ANGPT2、VEGFR-3、抵抗素含量都存在相关性(P<0.05)。Cox比例风险回归模型分析显示血清ANGPT2、VEGFR-3、抵抗素含量都为影响PASI评分的影响因素(P<0.05)。结论:血清ANGPT2、VEGFR-3、抵抗素水平在寻常型银屑病中呈现高表达状况,与患者的PASI评分存在相关性,可反映患者的病情状况。

Objective:To investigate the levels of serum Angiopoietin-like protein 2(ANGPT2),vascular endothelial cell specific receptor VEGF receptors(VEGF receptors,VEGFR)-3 and resistin(Resistin)in the vulgaris clinical significance in psoriasis.Methods:From September 2017 to June 2020,60 cases of patients with psoriasis vulgaris who were treated in the dermatology department of our hospital were selected as the case group,and 60 cases of healthy persons who received physical examination in our hospital during the same period were selected as the control group.The serum ANGPT2,VEGFR-3,and resistin levels of all the cases were detected,and the psoriasis area and severity index(PASI)scores of the case group were investigated and given the correlation analysis.Results:The contents of ANGPT2,VEGFR-3 and resistin in the case group[(4.69±0.44)ng/ml,(10.83±1.47)ng/ml,(267.02±45.10)ng/ml]were higher than those in the control group[(1.83±0.30)ng/ml,(8.02±2.15)ng/ml,(98.27±10.47)ng/ml](P<0.05).The PASI score of the case group were higher than that of the control group(P<0.05).In the case group,Pearson analysis showed that PASI score were correlated with serum ANGPT2,VEGFR-3,and resistin content(P<0.05).Cox proportional hazard regression model analysis showed that serum ANGPT2,VEGFR-3,and resistin levels were all influencing factors affected PASI score(P<0.05).Conclusion:Serum ANGPT2,VEGFR-3,and resistin levels are highly expressed in psoriasis vulgaris,and are correlated with the patient’s PASI score,which can reflect the patient’s condition.