某院体检部5年随访中使用非甾体抗炎药与患前列腺癌风险的相关性初探

Preliminary Study on the Relationship Between the Use of Non-steroidal Anti-inflammatory Drugs and the Risk of Prostate Cancer during the 5-Year Follow-up of the Physical Examination Department of One Hospital

目的分析老年男性非甾体类抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)的使用情况,并探讨其与前列腺癌发生风险的相关性。方法将某院体检部2014年6月~2015年5月进行健康体检符合纳入标准的老年男性作为研究对象,统计受试者对NSAIDs的使用情况,并通过5年的随访,记录受试者前列腺癌发病率,分析使用NSAIDs对前列腺发生风险的影响。结果纳入符合要求的老年男性1175名,根据NSAIDs使用情况分为NSAIDs组431名与非NSAIDs组744名,非NSAIDs组接受前列腺穿刺率、前列腺发病率均明显高于NSAIDs组(P<0.05)。非NSAIDs组确诊前列腺癌103例,NSAIDs组确诊前列腺癌29例,两组在临床基线资料中比较差异无统计学意义(P>0.05);非NSAIDs组随访5年后TPSA值、前列腺癌高级别(Gleason评分≥7分)、高临床分期(T分期≥T3)率均明显高于NSAIDs组,差异比较均具统计学意义(P<0.05)。相关性分析发现,使用NSAIDs、以及长期持续使用(≥3年)NSAIDs与前列腺癌发生风险降低均具有相关性(OR=1.06、1.04,95%CI=0.97~1.14、0.92~1.25,P均<0.05)。结论NSAIDs的应用与前列腺癌风险降低存在一定相关性,但是其长期用药的安全性与毒副作用仍有待进一步研究。

OBJECTIVE To analyze the use of non-steroidal anti-inflammatory drugs(NSAIDs)in elderly men,and explore its correlation with the risk of prostate cancer.METHODS Elderly men whose health checkups in the hospital physical examination center from June 2014 to May 2015 meet the inclusion criteria were taken as the research subjects,and the subjects'use of non-steroidal anti-inflammatory drugs were counted and the incidence of prostate cancer in the subjects were recorded through a 5-year follow-up,the influence of using non-steroidal anti-inflammatory drugs on the risk of prostate was analyzed.RESULTS One thousand one hundred and seventy-five qualified elderly men were included.According to the use of NSAIDs,they were divided into 431 in NSAIDs group and 744 in non-NSAIDs group.The non-NSAIDs group received prostate puncture and the incidence of prostate were significantly higher than those of NSAIDs group(P<0.05).One hundred and three cases of prostate cancer were diagnosed in the non-NSAIDs group,and 29 cases were diagnosed as prostate cancer in the NSAIDs group.There was no significant difference between the two groups in the clinical baseline data(P>0.05).The differences in indexes such as classification and T staging were statistically significant(P<0.05).Correlation analysis found that the use of NSAIDs and continuous long-term use of NSAIDs were associated with a reduction in the risk of prostate cancer(OR=1.06,1.04,95%CI=0.97-1.14,0.92-1.25,both P<0.05).CONCLUSION There is a certain correlation between the application of NSAIDs and the risk reduction of prostate cancer,but the safety and side effects of their long-term medications still need to be further studied.