非那雄胺固体分散体的制备、表征及体外溶出研究

Praparation,Characterization and Dissolution Study of Finasteride Solid Dispersion

目的:制备非那雄胺固体分散体。方法:使用溶剂挥发法制备非那雄胺-PEG 6000固体分散体,以非那雄胺溶解度作为评价手段筛选药物(非那雄胺)和载体(PEG 6000)的比例,并通过FT-IR、XRD和溶出仪对物相进行表征分析。结果:以PEG 6000为载体,药载比1:5时非那雄胺以无定形状态分布散开在PEG 6000骨架中,溶出度最高。结论:非那雄胺-PEG 6000固体分散体能显著地改善药物的溶解度和溶出度。

Purpose:To prepare Finasteride solid dispersion.Method:The Finasteride solid dispersion was prepared with PEG 6000 by solvent evaporation method.Characterization was performed by fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD)and dissolution test was also conducted to show the enhancement of dissolution rate.Results:The PEG 6000 can remarkablely improve the dissolution of Finasteride at the ratio of 1:5.Finasteride may be dispersed in carrier with an amorphous phase.Conclusion:Finasteride demonstrated obviously enhanced in vitro dissolution rate and solubility after being prepared into solid dispersion.