肾缺血再灌注损伤中坏死性凋亡的研究进展

Research Progress of Necroptosis in Renal Ischemia-Reperfusion Injury

缺血再灌注损伤(IRI)是器官血流短暂减少或停止,血流再灌注引发炎症产生的结果。肾脏对IRI敏感,缺血再灌注会导致严重的急性肾损伤,增加住院患者死亡率。坏死性凋亡是一种新的程序性细胞死亡方式,在肾IRI中发挥重要作用,通过调控坏死性凋亡的关键分子——受体相互作用蛋白激1/3、混合谱系激酶结构域样假激酶改善IRI器官功能。因此,充分理解肾IRI中坏死性凋亡的发生机制,有助于开发新的、有效治疗急性肾损伤的方法。

Ischemia-reperfusion injury(IRI)is the result of inflammation caused by transient reduction or cessation of organ blood flow and blood reperfusion.Kidney is sensitive to IRI,and ischemia-reperfusion can lead to severe acute renal injury and increase the mortality of hospitalized patients.Necroptosis is a newly discovered type of programmed cell death,which plays an very important role in renal IRI.It can improve the organ function of IRI by regulating the key molecular—receptor-interacting protein kinase 1/3,mixed lineage kinase domain like pseudokinase.Therefore,a full understanding of the mechanism of necroptosis in renal IRI will help to develop new and effective methods for the treatment of acute kidney injury.