摘要
脓毒症脑病(SAE)是脓毒症常见的并发症,与重症监护病房较高的病死率相关,同时也与SAE患者不良的预后以及长期的认知功能障碍相关。SAE的主要发病机制可能涉及神经递质功能障碍、脑部炎症性、缺血性病变以及血脑屏障功能障碍等。由于SAE的诊断标准及排除标准目前尚未达成共识,且无客观的诊断指标,患者总住院时间延长、伤残率和病死率升高。因此,针对SAE发病机制的研究具有重要临床意义,但目前SAE的病理生理机制尚未完全阐明,还有待未来进一步研究。
Sepsis-associated encephalopathy(SAE)is a kind of common complications of sepsis,which is related to a higher mortality in intensive care unit,and poor prognosis and long-term cognitive dysfunction of the SAE patients.The major pathogenesis of SAE may involve neurotransmitter dysfunction,brain inflammation,ischemic lesions,and blood-brain barrier dysfunction.There is no consensus on the diagnostic criteria and exclusion criteria of SAE,and the objective diagnostic indicators are still in lack,leading to prolonged hospitalization,and increased disability and mortality rate.Therefore,the research on the pathogenesis of SAE has great clinical significance,whereas currently pathophysiological mechanism of SAE has not yet been fully elucidated,and further research is needed in the future.
作者
李志强
周艺蕉
杨春燕
LI Zhiqiang;ZHOU Yijiao;YANG Chunyan(Department of Emergency Critical Care Medicine,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
出处
《医学综述》
CAS
2021年第19期3791-3795,共5页
Medical Recapitulate
基金
云南省教育厅科学研究基金(2021J0255)
昆明医科大学第二附属医院院内科技计划项目(2020yk009)。
关键词
脓毒症脑病
脓毒症
血脑屏障
Sepsis-associated encephalopathy
Sepsis
Blood-brain barrier