参松养心胶囊治疗高血压并发阵发性房颤的临床疗效及安全性分析

Analysis of the Safety and Clinical Effects of Shensong Yangxin Capsules in Treating Hypertension Complicated with Paroxysmal Atrial Fibrillation

目的:观察中药参松养心胶囊对高血压并发阵发性房颤的临床疗效及安全性。方法:选择高血压并发阵发性房颤患者110例,随机分为观察组和对照组,每组55例。两组均采用常规手段治疗,观察组在此基础上加用参松养心胶囊治疗。评价两组患者生活质量评分、运动耐量试验评分、临床疗效及不良反应发生情况。结果:观察组治疗3、6个月后阵发性房颤1周内发生次数明显少于对照组(P<0.05);观察组治疗后生活质量评分和6 min运动耐力评分均高于对照组(P<0.05);观察组总有效率[90.91%(50/55)]高于对照组[76.36%(42/55)](P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:参松养心胶囊治疗高血压并发阵发性房颤,可提高患者生活质量、运动耐量评分及总有效率,且无明显不良反应。

Objective:To explore clinical effects and the safety of Shensong Yangxin capsules in treating hypertension complicated with paroxysmal atrial fibrillation.Methods:All 110 hypertension patients complicated with paroxysmal atrial fibrillation were chosen and randomized into the control group and the observation group,55 cases in each group.Both groups adopted conventional therapy,and the observation group took Shensong Yangxin capsules orally.To assess the scores of quality of life and exercise tolerance test,clinical effects and the conditions of adverse reaction between both groups.Results:The frequency of paroxysmal atrial fibrillation within one week of the observation group after treating for three and six months was lower than that of the control group notably(P<0.05);the observation group was higher than the control group in the scores of quality of life and six minutes exercise tolerance test(P<0.05);total effective rate of the observation group was 90.91%(50/55),higher than 76.36%(42/55)of the control group(P<0.05);the difference had no statistical meaning in the incidence of adverse reaction between both groups(P>0.05).Conclusion:Shensong Yangxin capsules in treating hypertension complicated with paroxysmal atrial fibrillation could lift quality of life and the scores of exercise tolerance test,raise therapeutic effective rate without notable adverse reaction.