红细胞体积分布宽度、髓过氧化物酶与老年阻塞性睡眠呼吸暂停综合征严重程度的关系

Relationship between red blood cell volume distribution width,myeloperoxidase and the severity of obstructive sleep apnea syndrome in elderly patients

目的探讨红细胞体积分布宽度(RDW)、髓过氧化物酶(MPO)与老年阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrom,OSAS)严重程度的关系。方法选取2018年11月至2020年11月在郑州大学第一附属医院就诊的132例老年OSAS患者(OSAS组),以及同期体检排除OSAS的64例老年人(对照组)。所有研究对象均在入院后进行睡眠呼吸监测,记录呼吸暂停低通气指数(AHI),并根据AHI将OSAS患者进一步分为轻度(5~14次/h)、中度(15~29次/h)和重度(≥30次/h);另采集睡眠呼吸监测日清晨空腹静脉血,行血常规检查,并使用酶联免疫吸附法(ELISA)检测血清MPO水平。结果OSAS组RDW[(14.15±1.21)%VS(12.92±1.35)%]及血清MPO[(85.38±19.60)μg/L VS(41.86±7.92)μg/L]水平均显著高于对照组(P<0.05);轻度、中度和重度OSAS患者的RDW[(13.54±1.38)%、(14.06±1.27)%、(15.16±0.95)%]和血清MPO[(54.75±10.87)μg/L、(87.92±18.56)μg/L、(124.07±28.73)μg/L]水平差异均有统计学意义(P<0.05),随着病情程度加重,RDW及血清MPO水平逐渐升高,各组间比较差异有统计学意义(均P<0.05);Pearson相关分析显示RDW及血清MPO水平均与AHI呈显著正相关(均P<0.05)。结论RDW及血清MPO水平均与老年OSAS严重程度呈正相关,可能作为老年OSAS严重程度评估的潜在指标。

Objective To explore the relationship between red blood cell volume distribution width(RDW),myeloperoxidase(MPO)and the severity of obstructive sleep apnea syndrome(OSAS)in the elderly patients.Methods A total of 132 elderly patients with OSAS(OSAS group)who were admitted to the First Affiliated Hospital of Zhengzhou University from November 2018 to November 2020 were selected,and 64 elderly patients(control group)who were excluded from OSAS during physical examination during the same period were selected.All subjects underwent sleep respiration monitoring after admission,apnea hypopnea index(AHI)was recorded,and OSAS patients were further divided into mild(5~14 times/h),moderate(15~29 times/h),and severe(≥30 times/h)according to AHI.In addition,fasting venous blood was collected on the morning of sleep respiration monitoring day for routine blood examination,and serum MPO level was detected by enzyme-linked immunosorbent assay(ELISA).Results The levels of RDW[(14.15±1.21)%VS(12.92±1.35)%]and serum MPO[(85.38±19.60)μg/L VS(41.86±7.92)μg/L]in the OSAS group were significantly higher than those in the control group(P<0.05).The differences in levels of RDW[(13.54±1.38)%,(14.06±1.27)%,(15.16±0.95)%]and serum MPO[(54.75±10.87)μg/L,(87.92±18.56)μg/L,(124.07±28.73)μg/L]among the mild,moderate and severe groups were statistically significant(P<0.05).RDW and serum MPO levels increased gradually with the aggravation of the disease,and there were statistically significant differences among all groups(P<0.05).Pearson correlation analysis showed that RDW and serum MPO levels were significantlypositively correlated with AHI(P<0.05).Conclusion The levels of RDW and serum MPO are positively correlated with OSAS severity in the elderly,which may be applied as potential indicators to assess the severity of OSAS.