白细胞介素-8在前列腺癌发生发展中的作用

The role of interleukin-8 in the development and progression of prostate cancer

前列腺癌(prostate cancer,PCa)作为男性最常见的恶性肿瘤之一,严重威胁着中老年男性健康。目前PCa在预测、诊断、治疗和预后等方面面临着诸多挑战,虽然现阶段应用于临床的PCa生物标志物具有一定意义,但尚不能充分满足临床需求。细胞因子白细胞介素-8(interleukin-8,IL-8)已被证实在PCa的发生发展中起着重要作用,本文总结了IL-8在前列腺组织中的表达、IL-8相关信号传递通路以及其促进PCa发生和进展的机制,以期能够为PCa的诊断、治疗和预后评估提供参考。

Prostate cancer(PCa),as one of the most common malignant tumors in men poses a serious threat to the health of middle-aged and elderly males.At present,PCa presents many challenges in prediction,diagnosis,treatment and prognosis.Although various PCa biomarkers currently in used clinically have certain clinical significance,they do not fully meet the clinical needs.Cytokine interleukin-8(IL-8)may play an important role in the occurrence and development of PCa.This article summarizes the expression of IL-8 in prostate tissue,the signal transduction pathway related to IL-8 and the mechanism by which it promotes the occurrence and progression of PCa,in order to provide a reference for the diagnosis,treatment and prognosis of PCa.