病毒灭活冷冻干燥血浆制备工艺及应用研究进展

Research Advance on Preparation Technology and Application of Virus-inactivated Lyophilized Plasma——Review

冷冻干燥血浆在战伤救治等紧急情况下具有一定的应用优势。然而,冷冻干燥血浆面临两大问题,一是血浆病原体污染,研究表明,以病原体包膜或核酸为靶点的血浆病原体灭活技术可以保证其安全性;二是冷冻干燥后的质量损失,研究表明,向血浆中添加柠檬酸和甘氨酸可以有效维持复溶后血浆pH和蛋白活性。目前国外已有3种冷冻干燥血浆产品上市,我国尚无此类产品。因此,了解冷冻干燥血浆的研究进展,对于推进我国同类产品的研制有参考价值。

Lyophilized plasma has a certain advantage in emergency situation,such as war wound treatment.However,lyophilized plasma has two major problems,plasma pathogen pollution and mass loss after lyophilized.Studies have shown that plasma pathogen inactivation technology targeting pathogen envelope or nucleic acid can ensure its safety,and adding citric acid and glycine to plasma can effectively maintain pH and protein activity of plasma after reconstitution.At present,there are three kinds of lyophilized plasma products on the market abroad,but none for China.Therefore,understanding the research progress of lyophilized plasma may contribute to the development of similar products in China.