儿童脓毒症相关性脑病发生的危险因素分析

Risk factors of sepsis associated encephalopathy in children

目的分析脓毒症病儿发生脓毒症相关性脑病(SAE)的危险因素。方法选取2018年1月至2020年2月入住徐州市儿童医院的脓毒症病儿158例,其中符合SAE诊断标准病儿57例,未发生SAE病儿101例,通过单因素分析和多因素回归等方法,研究脓毒症病儿发生SAE的危险因素。结果SAE组病儿死亡率(29.8%)高于非SAE组(9.9%),差异有统计学意义(P<0.05)。凝血功能障碍、高同型半胱氨酸血症、高尿酸血症是儿童SAE发生的独立危险因素,差异有统计学意义(P<0.05)。结论凝血功能障碍、高同型半胱氨酸血症、高尿酸血症对脓毒症病儿是否发生SAE有一定预测价值。

Objective To analyze the risk factors of sepsis associated encephalopathy(SAE)in children with sepsis.Methods One hundred and fifty-eight children with sepsis admitted to Xuzhou Children's Hospital from January 2018 to February 2020 were select‐ed.Among them,57 children met the SAE diagnostic criteria and 101 children did not have SAE.The risk factors of SAE in children with sepsis were studied by univariate analysis and multivariate regression.Results The mortality rate of SAE group(29.8%)was high‐er than that of non-SAE group(9.9%),and the difference was statistically significant(P<0.05).Coagulation dysfunction,hyperhomocys‐teinemia and hyperuricemia were independent risk factors of SAE in children,and the difference was statistically significant(P<0.05).Conclusion Coagulation dysfunction,hyperhomocysteinemia and hyperuricemia have certain predictive value for the occurrence of SAE in children with sepsis.