摘要
消化系统是人体最大的内分泌器官,胃肠激素广泛参与调控生理代谢,并不限于营养吸收.自1902年发现第一个胃肠激素——促胰液素以来,该领域研究持续深入,诊疗新技术不断涌现,极大地丰富了人们对消化生理和人体代谢的认识,且提升了胃肠激素相关疾病(例如神经内分泌肿瘤)的诊治水平.胃肠激素及其类似物成为消化和代谢性疾病新的治疗选择.本文综述了百年来胃肠激素研究的历程,以期体现基础与临床互相渗透、互相促进的转化医学思想.
The gut is the largest endocrine organ of the body.Gut hormones extensively modulate metabolic activities beyond digestion and absorption of nutrients.The first gut hormone,secretin,was discovered in 1902.Ever since,this area has witnessed a series of indepth studies leading to novel diagnostic and therapeutic methods.Studies in this area have greatly enriched our understanding of gastrointestinal physiology and metabolic functions,and have improved the management of gut hormone-related diseases such as neuroendocrine neoplasm.Gut hormones and their analogs are becoming new therapy of choice for digestive and metabolic diseases.This article reviews a centenary progression of gut endocrinology to reflect the essence of translational research,e.g.,the mutual interplay and promotion between clinical and basic medicine.
作者
吴东
李景南
杨爱明
钱家鸣
WU Dong;LI JingNan;YANG AiMing;QIAN JiaMing(State Key Laboratory of Complex Severe and Rare Diseases,Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2021年第8期920-926,共7页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2020YFC2002702)
北京市自然科学基金(批准号:7192162)
北京协和医学院基金(批准号:2019zlgc0503)
中国医学科学院基金(批准号:2019XK320036)资助。
关键词
胃肠激素
神经内分泌肿瘤
转化医学
gut hormone
neuroendocrine neoplasm
translational medicine
