垂体腺瘤诊治的最新进展

An update on the clinical diagnosis and treatment of pituitary adenomas

垂体腺瘤是颅内常见肿瘤,多为良性,但因其自身激素分泌和/或对周围腺垂体及组织器官的压迫,严重影响患者的生活质量和预后.2017年世界卫生组织提出了垂体腺瘤新分型,以垂体分化为基础,根据腺垂体细胞谱系对垂体腺瘤进行分类,这对临床诊治策略和肿瘤预后预测具有重要的指导价值.难治性垂体腺瘤的诊治仍然是一个世界性的难题,近年来对其定义和治疗有较多进展.多学科团队协作是垂体腺瘤诊治的基石,患者将从垂体瘤卓越中心获得最佳的诊断和治疗.本文系统综述了近年来国内外垂体腺瘤诊断和治疗的最新进展.

Pituitary adenomas are one of the most common intracranial tumors and mostly benign.However,due to their pathophysiologic endocrine secretion and anatomic compression of surrounding tissues and structures,they potentially lead to significant morbidity and poor prognosis.In 2017,the World Health Organization proposed a new classification of pituitary adenomas.Based on pituitary differentiation,pituitary adenomas are classified according to the lineage of pituitary cells.This has important guiding values for clinical management strategies and prediction of tumor prognosis.The diagnosis and treatment of aggressive/refractory pituitary adenomas is still a worldwide problem.In recent years,much progress has been made in its definition and treatment.Multiple disciplinary team is the cornerstone of the diagnosis and treatment of pituitary adenomas.Patients will get the best possible medical care and treatment from the Pituitary Tumors Centers of Excellence.The latest advances in the diagnosis and treatment of pituitary adenomas are systematically reviewed.