Effects of Ferulic Sesquiterpene Compounds on Schistosoma japonicum at Different Developmental Stages in Infected Juvenile Rabbits

[Objectives]This study was conducted to explore the effects of ferulic sesquiterpene compounds on juvenile worms and adults of Schistosoma japonicum at different developmental stages in infected juvenile rabbits.[Methods]Juvenile rabbits were infected with S.japonicum quantitatively,and administered with 500 mg/kg ferulic sesquiterpene compounds at 2 h,1,2,6,11,13,15,24,36,and 41 d after infection by gavage,1 time/d,and a control group was administrated with normal saline.After 4 weeks of administration,the juvenile rabbits were dissected,and the worms were collected by portal vein perfusion for the calculation of worm reduction rate.[Results]The reduction rates of ferulic sesquiterpene compounds on 1,2,6,11,13,15,24,36,and 41-day-old juveniles or adults were 15.8%,17.0%,60.2%,50.2%,36.9%,31.3%,45.3%,57.0%,and 25.2%,respectively,and it was found that worms at the age of 6-36 d were most sensitive to the drug.[Conclusions]Ferulic sesquiterpene compounds had a killing effect on S.japonicum at different developmental stages in juvenile rabbits,and the killing effect on 6-36-day-old worms was more significant.