基于巨噬细胞的纳米仿生递药系统在肿瘤治疗中的应用

Application of nano-bionic drug delivery system based on macrophages in tumor therapy

利用细胞及细胞成分构建纳米仿生递药系统是目前新型药物递送系统的研究热点。该纳米仿生递药系统可整合纳米载体高载药量、可控释药和细胞仿生成分良好生物相容性、低免疫原性、天然靶向性及活细胞形态灵活特征。其中,巨噬细胞因其吞噬功能、固有趋向性、深层渗透能力及在细胞治疗中的潜力,基于巨噬细胞的纳米仿生递药系统在肿瘤治疗方面展现出良好临床应用前景。基于此,本综述基于巨噬细胞的纳米仿生递药系统载药策略及其在肿瘤治疗中的应用,以期为新型递药系统的研发提供参考。

The construction of nano-bionic drug delivery system based on cells or cellular components is a research hotspot of novel drug delivery systems at present. The nano-bionic drug delivery system can integrate the characteristics not only high drug loading and controlled release of nano-carriers, but also good biocompatibility,low immunogenicity and natural targeting from bionic components of cell, and it can also integrate with flexible morphology from living cells. Among them, nano-bionic drug delivery system based on macrophages possesses a good prospect of clinical application because of phagocytic function, inherent tendency, deep penetration ability and potential in cell therapy of macrophages in the treatment of tumors. Based on this, this paper reviews the drug loading strategies of nano-bionic drug delivery system based on macrophages and its application in tumor therapy,so as to provide reference for the development of novel drug delivery systems.